DegronMD - Q02641(CACNB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P414Q	TCGA-BF-A1PU	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7035
p.P414Q	DO50278	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7035
p.R202C	DO233237	GACA	ICGC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.2778
p.P204H	DO233748	GACA	ICGC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation altering degron motif	0.7694
p.P206T	DO229019	LICA	ICGC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation altering degron motif	0.7031
p.T199S	DO222494	MELA	ICGC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.1944
p.S216L	DO222413	MELA	ICGC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.1389
p.Q424R	DO36269	PRAD	ICGC	PPSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1667
p.Q415H	DO41758	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7582
p.P422L	SIDM01293	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.2222
p.T201A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.25
p.T201A	ACH-000995	Leukemia	CCLE	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.25
p.H219N	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.0556
p.H219N	ACH-000795	Leukemia	CCLE	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.0556
p.H219N	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.0556
p.L216F	SIDM00845	Burkitt's Lymphoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.1389
p.H219Q	SIDM00489	Oral Cavity Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.0556
p.H219Q	ACH-002043	Head and Neck Cancer	CCLE	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.0556
p.H219Q	Ca9-22	upper aerodigestive tract	COSMIC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.0556
p.W409S	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1944
p.W409S	ACH-000951	Lung Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1944
p.W409S	NCI-H2342	lung	COSMIC	PPSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1944
p.S417N	SIDM01617	Endometrial Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7069
p.S417N	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7069
p.A214V	SW1116	large intestine	COSMIC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.1944
p.A212E	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation rewiring degron network	0.25
p.C213S	Ca9-22	upper aerodigestive tract	COSMIC	PTPPAS	DEG_SCF_FBW7_1	204:209	Mutation substituting flanking lysine	0.3333

Kaplan plot for CACNB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNB1

UniProt ID: Q02641

Entrez ID: 782

Protein name: Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CACNB1 in