DegronMD

Uniprot ID: Q02641

Source protein: Voltage-dependent L-type calcium channel subunit beta-1

Source gene: CACNB1

Class: DEG_SCF_FBW7_1

Location: 204:209

E3 ligase: FBXW7

DEGRON score: 0.9841

ASA_SCORE: 72.05

COIL: 0.8705

CONS_SCORE: 0.5909

DSS_SCORE: 0.755

HELIX: 0.0722

FCONS_SCORE: 1.0917

RIG_SCORE: 0.6042

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R202C	DO233237	GACA	ICGC	PTPPAS	DEG_SCF_FBW7_1	0.2778
p.P204H	DO233748	GACA	ICGC	PTPPAS	DEG_SCF_FBW7_1	0.7694
p.P206T	DO229019	LICA	ICGC	PTPPAS	DEG_SCF_FBW7_1	0.7031
p.T199S	DO222494	MELA	ICGC	PTPPAS	DEG_SCF_FBW7_1	0.1944
p.S216L	DO222413	MELA	ICGC	PTPPAS	DEG_SCF_FBW7_1	0.1389
p.T201A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.25
p.T201A	ACH-000995	Leukemia	CCLE	PTPPAS	DEG_SCF_FBW7_1	0.25
p.H219N	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.0556
p.H219N	ACH-000795	Leukemia	CCLE	PTPPAS	DEG_SCF_FBW7_1	0.0556
p.H219N	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.0556
p.L216F	SIDM00845	Burkitt's Lymphoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.1389
p.H219Q	SIDM00489	Oral Cavity Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.0556
p.H219Q	ACH-002043	Head and Neck Cancer	CCLE	PTPPAS	DEG_SCF_FBW7_1	0.0556
p.H219Q	Ca9-22	upper_aerodigestive_tract	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.0556
p.A214V	SW1116	large_intestine	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.1944
p.A212E	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.25
p.C213S	Ca9-22	upper_aerodigestive_tract	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02641	Voltage-dependent L-type calcium channel subunit beta-1	DEG_SCF_FBW7_1	204:209	PTPPAS	FBXW7	0.9841	More...
Q9H6A9	Pecanex-like protein 3	DEG_SCF_FBW7_1	598:603	PTPPAS	FBXW7	0.9972	More...
Q9ULN7	Paraneoplastic antigen-like protein 8B	DEG_SCF_FBW7_1	128:133	PTPPAS	FBXW7	0.9794	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons