DegronMD - Q9ULN7(PNMA8B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R251S	SIDM00454	Rhabdomyosarcoma	GDSC	PREFLALVT	DEG_APCC_DBOX_1	250:258	Mutation altering degron motif	0.7427
p.R251S	SIDM00793	Burkitt's Lymphoma	GDSC	PREFLALVT	DEG_APCC_DBOX_1	250:258	Mutation altering degron motif	0.7427
p.R251S	SIDM00068	Colorectal Carcinoma	GDSC	PREFLALVT	DEG_APCC_DBOX_1	250:258	Mutation altering degron motif	0.7427
p.R251S	SIDM01173	Rhabdomyosarcoma	GDSC	PREFLALVT	DEG_APCC_DBOX_1	250:258	Mutation altering degron motif	0.7427
p.A132T	SIDM00064	Hepatocellular Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.6028
p.A132T	HLE	liver	COSMIC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.6028
p.P130R	SIDM00938	Breast Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.7512
p.P130R	SIDM01177	B-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.7512
p.P130R	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.7512
p.P130R	SIDM00674	Non-Cancerous	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.7512
p.P130R	SIDM00675	Breast Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.7512
p.T135M	SIDM00444	Esophageal Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation rewiring degron network	0.2778
p.T135M	OACM5-1	oesophagus	COSMIC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation rewiring degron network	0.2778
p.D139Y	SIDM00596	Endometrial Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation rewiring degron network	0.1667
p.D139Y	HEC-1	endometrium	COSMIC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation rewiring degron network	0.1667
p.A121V	SIDM00516	Melanoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation rewiring degron network	0.1389
p.A121V	MZ7-mel	skin	COSMIC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation rewiring degron network	0.1389
p.T129N	SIDM00105	Ovarian Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.7055
p.T129N	OVCAR-3	ovary	COSMIC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.7055
p.S133L	SIDM00118	Colorectal Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.7667
p.S133L	HCC2998	large intestine	COSMIC	PTPPAS	DEG_SCF_FBW7_1	128:133	Mutation altering degron motif	0.7667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PNMA8B

UniProt ID: Q9ULN7

Entrez ID: 57469

Protein name: Paraneoplastic antigen-like protein 8B (PNMA-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PNMA8B in