DegronMD

Uniprot ID: Q9ULN7

Source protein: Paraneoplastic antigen-like protein 8B

Source gene: PNMA8B

Class: DEG_APCC_DBOX_1

Location: 250:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6345

ASA_SCORE: 57.8556

COIL: 0.2434

CONS_SCORE: 0.9944

DSS_SCORE: 0.525

HELIX: 0.7048

FCONS_SCORE: 1.3518

RIG_SCORE: 0.7851

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R251S	SIDM00454	Rhabdomyosarcoma	GDSC	PREFLALVT	DEG_APCC_DBOX_1	0.7427
p.R251S	SIDM00793	Burkitt's Lymphoma	GDSC	PREFLALVT	DEG_APCC_DBOX_1	0.7427
p.R251S	SIDM00068	Colorectal Carcinoma	GDSC	PREFLALVT	DEG_APCC_DBOX_1	0.7427
p.R251S	SIDM01173	Rhabdomyosarcoma	GDSC	PREFLALVT	DEG_APCC_DBOX_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULN7	Paraneoplastic antigen-like protein 8B	DEG_APCC_DBOX_1	250:258	PREFLALVT	APC,CDC20,FZR1	0.6345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons