DegronMD

Uniprot ID: Q9ULN7

Source protein: Paraneoplastic antigen-like protein 8B

Source gene: PNMA8B

Class: DEG_SCF_FBW7_1

Location: 128:133

E3 ligase: FBXW7

DEGRON score: 0.9794

ASA_SCORE: 65.0333

COIL: 0.8598

CONS_SCORE: 0.5363

DSS_SCORE: 0.8924

HELIX: 0.0992

FCONS_SCORE: 1.0961

RIG_SCORE: 0.5817

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A132T	SIDM00064	Hepatocellular Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.6028
p.A132T	HLE	liver	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.6028
p.P130R	SIDM00938	Breast Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.7512
p.P130R	SIDM01177	B-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.7512
p.P130R	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.7512
p.P130R	SIDM00674	Non-Cancerous	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.7512
p.P130R	SIDM00675	Breast Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.7512
p.T135M	SIDM00444	Esophageal Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.2778
p.T135M	OACM5-1	oesophagus	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.2778
p.D139Y	SIDM00596	Endometrial Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.1667
p.D139Y	HEC-1	endometrium	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.1667
p.A121V	SIDM00516	Melanoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.1389
p.A121V	MZ7-mel	skin	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.1389
p.T129N	SIDM00105	Ovarian Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.7055
p.T129N	OVCAR-3	ovary	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.7055
p.S133L	SIDM00118	Colorectal Carcinoma	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.7667
p.S133L	HCC2998	large_intestine	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02641	Voltage-dependent L-type calcium channel subunit beta-1	DEG_SCF_FBW7_1	204:209	PTPPAS	FBXW7	0.9841	More...
Q9H6A9	Pecanex-like protein 3	DEG_SCF_FBW7_1	598:603	PTPPAS	FBXW7	0.9972	More...
Q9ULN7	Paraneoplastic antigen-like protein 8B	DEG_SCF_FBW7_1	128:133	PTPPAS	FBXW7	0.9794	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons