DegronMD

Uniprot ID: Q9H6A9

Source protein: Pecanex-like protein 3

Source gene: PCNX3

Class: DEG_SCF_FBW7_1

Location: 598:603

E3 ligase: FBXW7

DEGRON score: 0.9972

ASA_SCORE: 78.0833

COIL: 0.923

CONS_SCORE: 0.4029

DSS_SCORE: 0.814

HELIX: 0.0523

FCONS_SCORE: 0.9911

RIG_SCORE: 0.5449

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R590T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.1111
p.P600S	SIDM01003	T-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.6752
p.P600S	KE-37	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.6752
p.P598L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.6471
p.P598L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPAS	DEG_SCF_FBW7_1	0.6471
p.S603F	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTPPAS	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02641	Voltage-dependent L-type calcium channel subunit beta-1	DEG_SCF_FBW7_1	204:209	PTPPAS	FBXW7	0.9841	More...
Q9H6A9	Pecanex-like protein 3	DEG_SCF_FBW7_1	598:603	PTPPAS	FBXW7	0.9972	More...
Q9ULN7	Paraneoplastic antigen-like protein 8B	DEG_SCF_FBW7_1	128:133	PTPPAS	FBXW7	0.9794	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons