DegronMD - Q9C0D6(FHDC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1051I	TCGA-06-5416	GBM	TCGA	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation altering degron motif	0.7174
p.L1051I	DO10880	GBM	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation altering degron motif	0.7174
p.H1027Q	TCGA-09-2053	OV	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.2778
p.H1027Q	DO31060	OV	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.2778
p.A1036S	TCGA-13-0755	OV	TCGA	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.2222
p.A1036S	DO28056	OV	ICGC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.2222
p.A1036S	SIDM00614	Hepatocellular Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.2222
p.A1036S	ACH-000848	Liver Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.2222
p.A1036S	JHH-7	liver	COSMIC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.2222
p.G926V	TCGA-22-A5C4	LUSC	TCGA	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1944
p.G926V	DO45446	LUSC	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1944
p.R729T	TCGA-44-3918	LUAD	TCGA	GRDALGSLS	DEG_APCC_DBOX_1	728:736	Mutation altering degron motif	0.7876
p.R729T	TCGA-UY-A78P	BLCA	TCGA	GRDALGSLS	DEG_APCC_DBOX_1	728:736	Mutation altering degron motif	0.7876
p.R729T	DO48386	BLCA	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	728:736	Mutation altering degron motif	0.7876
p.R729T	DO219036	BLCA	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	728:736	Mutation altering degron motif	0.7876
p.R729T	DO218173	BRCA	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	728:736	Mutation altering degron motif	0.7876
p.R729T	DO23732	LUAD	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	728:736	Mutation altering degron motif	0.7876
p.A1005T	TCGA-55-8085	LUAD	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.0556
p.A1005T	DO45326	LUAD	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.0556
p.L717H	TCGA-73-4658	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	719:723	Mutation rewiring degron network	0.2778
p.L717H	DO23663	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	719:723	Mutation rewiring degron network	0.2778
p.E1011Q	TCGA-93-8067	LUAD	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.2222
p.E1011Q	DO25113	LUAD	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.2222
p.S734R	TCGA-A5-A0G1	UCEC	TCGA	GRDALGSLS	DEG_APCC_DBOX_1	728:736	Mutation altering degron motif	0.6316
p.S734R	DO42472	UCEC	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	728:736	Mutation altering degron motif	0.6316
p.E1028K	TCGA-AA-3984	COAD	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.25
p.E1028K	TCGA-EI-6917	READ	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.25
p.E1028K	DO9002	COAD	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.25
p.E1028K	DO223149	ESCA	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.25
p.E1028K	DO36881	READ	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.25
p.V709M	TCGA-AC-A23H	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	719:723	Mutation rewiring degron network	0.0556
p.V709M	DO2401	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	719:723	Mutation rewiring degron network	0.0556
p.P1023T	TCGA-AR-A2LE	BRCA	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation altering degron motif	0.7031
p.P1023T	DO1932	BRCA	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation altering degron motif	0.7031
p.T937N	TCGA-AX-A06F	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.2778
p.T937N	DO232761	PBCA	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.2778
p.T937N	DO41752	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.2778
p.G1009D	TCGA-B5-A11E	UCEC	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1667
p.G1009D	DO41644	UCEC	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1667
p.R1031C	TCGA-CM-6162	COAD	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1667
p.R1031C	TCGA-CM-6162	COAD	TCGA	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.0833
p.R1031C	DO8479	COAD	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1667
p.R1031C	DO8479	COAD	ICGC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.0833
p.P927S	TCGA-D3-A5GO	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.2222
p.P927S	DO47419	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.2222
p.P1010S	TCGA-D3-A5GO	SKCM	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1944
p.P1010S	DO220899	MELA	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1944
p.P1010S	DO47419	SKCM	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1944
p.P1010S	ACH-002396	Bone Cancer	CCLE	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1944
p.P1010S	Sarc9371	bone	COSMIC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1944
p.S1065L	TCGA-D3-A8GI	SKCM	TCGA	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.0556
p.S1065L	DO50284	SKCM	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.0556
p.G560S	TCGA-D5-6539	COAD	TCGA	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.2222
p.G560S	DO7950	COAD	ICGC	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.2222
p.P931L	TCGA-D9-A6EA	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	931:935	Mutation altering degron motif	0.7582
p.P931L	DO222407	MELA	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation altering degron motif	0.7582
p.P931L	DO50290	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation altering degron motif	0.7582
p.R941C	TCGA-DD-AAEE	LIHC	TCGA	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1667
p.R941C	DO52270	LIHC	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1667
p.P1052H	TCGA-E6-A1LX	UCEC	TCGA	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation altering degron motif	0.6583
p.P1052H	DO41020	UCEC	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation altering degron motif	0.6583
p.S944F	TCGA-EB-A44O	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0833
p.S944F	DO47272	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0833
p.S928Y	TCGA-EE-A29S	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.25
p.S928Y	DO37936	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.25
p.P545L	TCGA-EE-A29V	SKCM	TCGA	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.25
p.P545L	DO38006	SKCM	ICGC	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.25
p.R1031S	TCGA-EE-A2MN	SKCM	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1667
p.R1031S	TCGA-EE-A2MN	SKCM	TCGA	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.0833
p.R1031S	DO37423	SKCM	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1667
p.R1031S	DO37423	SKCM	ICGC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.0833
p.R941G	TCGA-EE-A3AE	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1667
p.R941G	DO37802	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1667
p.R549L	TCGA-ER-A19C	SKCM	TCGA	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation altering degron motif	0.8428
p.R549L	DO47353	SKCM	ICGC	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation altering degron motif	0.8428
p.P1020L	TCGA-F7-A624	HNSC	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation altering degron motif	0.6471
p.P1020L	DO44440	HNSC	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation altering degron motif	0.6471
p.R1062Q	TCGA-FR-A726	SKCM	TCGA	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.1389
p.R1062Q	TCGA-P3-A6T7	HNSC	TCGA	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.1389
p.R1062Q	DO49033	HNSC	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.1389
p.R1062Q	DO48665	SKCM	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.1389
p.S1043T	TCGA-FR-A8YC	SKCM	TCGA	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.6005
p.S1043T	DO50301	SKCM	ICGC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.6005
p.S1034R	TCGA-QQ-A8VF	SARC	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation blocking phosphorylation signal	0.5278
p.S1034R	TCGA-QQ-A8VF	SARC	TCGA	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation blocking phosphorylation signal	0.6111
p.S1034R	DO220258	SARC	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation blocking phosphorylation signal	0.5278
p.S1034R	DO220258	SARC	ICGC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation blocking phosphorylation signal	0.6111
p.E563Q	TCGA-UY-A8OC	BLCA	TCGA	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.1389
p.E563Q	DO219038	BLCA	ICGC	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.1389
p.E1011D	TCGA-UY-A8OC	BLCA	TCGA	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.2222
p.E1011D	DO219038	BLCA	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.2222
p.R925Q	DO234181	ESAD	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1667
p.R1062L	DO233780	GACA	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.1389
p.I1060V	DO228188	LICA	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.1944
p.R1031L	DO228974	LICA	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1667
p.R1031L	DO228974	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.0833
p.Q929H	DO228971	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.2778
p.A1055S	DO229038	LICA	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation altering degron motif	0.6477
p.R941L	DO229037	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1667
p.V1032F	DO229041	LICA	ICGC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation rewiring degron network	0.1389
p.V1032F	DO229041	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.1111
p.S1046N	DO50970	LICA	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation blocking phosphorylation signal	0.75
p.S1046N	DO50970	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation blocking phosphorylation signal	0.7222
p.V945M	DO227759	PBCA	ICGC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0556
p.R1037Q	DO48930	PBCA	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.0556
p.R1037Q	DO48930	PBCA	ICGC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation rewiring degron network	0.25
p.A738E	DO229213	THCA	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	728:736	Mutation rewiring degron network	0.2778
p.V1025I	SIDM00973	Melanoma	GDSC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation altering degron motif	0.5965
p.V1025I	SIDM01110	Hepatocellular Carcinoma	GDSC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation altering degron motif	0.5965
p.V1025I	SIDM01692	T-Cell Non-Hodgkin's Lymphoma	GDSC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation altering degron motif	0.5965
p.V1025I	SIDM01475	Ovarian Carcinoma	GDSC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation altering degron motif	0.5965
p.V1025I	SIDM01590	Breast Carcinoma	GDSC	EEPKTPSVPSV	DEG_COP1_1	1015:1025	Mutation altering degron motif	0.5965
p.A1041S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.6477
p.A1041S	ACH-000924	Lung Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.6477
p.A1041S	NCI-H2172	lung	COSMIC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.6477
p.A1041V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.5825
p.A1041V	ACH-002256	Leukemia	CCLE	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.5825
p.A1041V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.5825
p.S933N	SIDM00190	Melanoma	GDSC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation altering degron motif	0.7069
p.S933N	ACH-002097	Skin Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	931:935	Mutation altering degron motif	0.7069
p.S933N	CP66-MEL	skin	COSMIC	PPSST	DEG_SPOP_SBC_1	931:935	Mutation altering degron motif	0.7069
p.S1042A	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.7588
p.S1042A	HCE-4	oesophagus	COSMIC	VASSS	DEG_SPOP_SBC_1	1040:1044	Mutation altering degron motif	0.7588
p.R540H	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.1111
p.R540H	ACH-000980	Lung Cancer	CCLE	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.1111
p.R540H	NCI-H1155	lung	COSMIC	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.1111
p.N566S	SIDM00792	Small Cell Lung Carcinoma	GDSC	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.0556
p.N566S	ACH-002170	Lung Cancer	CCLE	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.0556
p.N566S	NCI-H1688	lung	COSMIC	DRELLTFLE	DEG_APCC_DBOX_1	548:556	Mutation rewiring degron network	0.0556
p.T1063K	SIDM01525	Acute Myeloid Leukemia	GDSC	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.1111
p.T1063K	ACH-000557	Leukemia	CCLE	MRTDLPPVA	DEG_APCC_DBOX_1	1047:1055	Mutation rewiring degron network	0.1111
p.P714L	NCI-H630	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	719:723	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FHDC1

UniProt ID: Q9C0D6

Entrez ID: 85462

Protein name: FH2 domain-containing protein 1 (Inverted formin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FHDC1 in