DegronMD

Uniprot ID: Q9C0D6

Source protein: FH2 domain-containing protein 1

Source gene: FHDC1

Class: DEG_APCC_DBOX_1

Location: 548:556

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.953

ASA_SCORE: 92.1111

COIL: 0.3402

CONS_SCORE: 0.6924

DSS_SCORE: 0.6175

HELIX: 0.6394

FCONS_SCORE: 1.0628

RIG_SCORE: 0.7245

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G560S	TCGA-D5-6539	COAD	TCGA	DRELLTFLE	DEG_APCC_DBOX_1	0.2222
p.G560S	DO7950	COAD	ICGC	DRELLTFLE	DEG_APCC_DBOX_1	0.2222
p.P545L	TCGA-EE-A29V	SKCM	TCGA	DRELLTFLE	DEG_APCC_DBOX_1	0.25
p.P545L	DO38006	SKCM	ICGC	DRELLTFLE	DEG_APCC_DBOX_1	0.25
p.R549L	TCGA-ER-A19C	SKCM	TCGA	DRELLTFLE	DEG_APCC_DBOX_1	0.8428
p.R549L	DO47353	SKCM	ICGC	DRELLTFLE	DEG_APCC_DBOX_1	0.8428
p.E563Q	TCGA-UY-A8OC	BLCA	TCGA	DRELLTFLE	DEG_APCC_DBOX_1	0.1389
p.E563Q	DO219038	BLCA	ICGC	DRELLTFLE	DEG_APCC_DBOX_1	0.1389
p.R540H	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DRELLTFLE	DEG_APCC_DBOX_1	0.1111
p.R540H	ACH-000980	Lung Cancer	CCLE	DRELLTFLE	DEG_APCC_DBOX_1	0.1111
p.R540H	NCI-H1155	lung	COSMIC	DRELLTFLE	DEG_APCC_DBOX_1	0.1111
p.N566S	SIDM00792	Small Cell Lung Carcinoma	GDSC	DRELLTFLE	DEG_APCC_DBOX_1	0.0556
p.N566S	ACH-002170	Lung Cancer	CCLE	DRELLTFLE	DEG_APCC_DBOX_1	0.0556
p.N566S	NCI-H1688	lung	COSMIC	DRELLTFLE	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D6	FH2 domain-containing protein 1	DEG_APCC_DBOX_1	548:556	DRELLTFLE	APC,CDC20,FZR1	0.953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons