DegronMD

Uniprot ID: Q9C0D6

Source protein: FH2 domain-containing protein 1

Source gene: FHDC1

Class: DEG_APCC_DBOX_1

Location: 1047:1055

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9943

ASA_SCORE: 103.1778

COIL: 0.925

CONS_SCORE: 0.5777

DSS_SCORE: 0.6214

HELIX: 0.0521

FCONS_SCORE: 0.9801

RIG_SCORE: 0.688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1051I	TCGA-06-5416	GBM	TCGA	MRTDLPPVA	DEG_APCC_DBOX_1	0.7174
p.L1051I	DO10880	GBM	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	0.7174
p.S1065L	TCGA-D3-A8GI	SKCM	TCGA	MRTDLPPVA	DEG_APCC_DBOX_1	0.0556
p.S1065L	DO50284	SKCM	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	0.0556
p.P1052H	TCGA-E6-A1LX	UCEC	TCGA	MRTDLPPVA	DEG_APCC_DBOX_1	0.6583
p.P1052H	DO41020	UCEC	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	0.6583
p.R1062Q	TCGA-FR-A726	SKCM	TCGA	MRTDLPPVA	DEG_APCC_DBOX_1	0.1389
p.R1062Q	TCGA-P3-A6T7	HNSC	TCGA	MRTDLPPVA	DEG_APCC_DBOX_1	0.1389
p.R1062Q	DO49033	HNSC	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	0.1389
p.R1062Q	DO48665	SKCM	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	0.1389
p.R1062L	DO233780	GACA	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	0.1389
p.I1060V	DO228188	LICA	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	0.1944
p.A1055S	DO229038	LICA	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	0.6477
p.S1046N	DO50970	LICA	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	0.75
p.R1037Q	DO48930	PBCA	ICGC	MRTDLPPVA	DEG_APCC_DBOX_1	0.0556
p.T1063K	SIDM01525	Acute Myeloid Leukemia	GDSC	MRTDLPPVA	DEG_APCC_DBOX_1	0.1111
p.T1063K	ACH-000557	Leukemia	CCLE	MRTDLPPVA	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D6	FH2 domain-containing protein 1	DEG_APCC_DBOX_1	1047:1055	MRTDLPPVA	APC,CDC20,FZR1	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons