DegronMD

Uniprot ID: Q9C0D6

Source protein: FH2 domain-containing protein 1

Source gene: FHDC1

Class: DEG_COP1_1

Location: 1015:1025

E3 ligase: COP1

DEGRON score: 0.9733

ASA_SCORE: 103.5455

COIL: 0.9604

CONS_SCORE: 0.5096

DSS_SCORE: 0.7239

HELIX: 0.0166

FCONS_SCORE: 0.9065

RIG_SCORE: 0.5441

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1027Q	TCGA-09-2053	OV	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.2778
p.H1027Q	DO31060	OV	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.2778
p.A1005T	TCGA-55-8085	LUAD	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.0556
p.A1005T	DO45326	LUAD	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.0556
p.E1011Q	TCGA-93-8067	LUAD	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.2222
p.E1011Q	DO25113	LUAD	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.2222
p.E1028K	TCGA-AA-3984	COAD	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.25
p.E1028K	TCGA-EI-6917	READ	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.25
p.E1028K	DO9002	COAD	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.25
p.E1028K	DO223149	ESCA	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.25
p.E1028K	DO36881	READ	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.25
p.P1023T	TCGA-AR-A2LE	BRCA	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.7031
p.P1023T	DO1932	BRCA	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.7031
p.G1009D	TCGA-B5-A11E	UCEC	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.1667
p.G1009D	DO41644	UCEC	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.1667
p.R1031C	TCGA-CM-6162	COAD	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.1667
p.R1031C	DO8479	COAD	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.1667
p.P1010S	TCGA-D3-A5GO	SKCM	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.1944
p.P1010S	DO220899	MELA	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.1944
p.P1010S	DO47419	SKCM	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.1944
p.P1010S	ACH-002396	Bone Cancer	CCLE	EEPKTPSVPSV	DEG_COP1_1	0.1944
p.P1010S	Sarc9371	bone	COSMIC	EEPKTPSVPSV	DEG_COP1_1	0.1944
p.R1031S	TCGA-EE-A2MN	SKCM	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.1667
p.R1031S	DO37423	SKCM	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.1667
p.P1020L	TCGA-F7-A624	HNSC	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.6471
p.P1020L	DO44440	HNSC	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.6471
p.S1034R	TCGA-QQ-A8VF	SARC	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.5278
p.S1034R	DO220258	SARC	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.5278
p.E1011D	TCGA-UY-A8OC	BLCA	TCGA	EEPKTPSVPSV	DEG_COP1_1	0.2222
p.E1011D	DO219038	BLCA	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.2222
p.R1031L	DO228974	LICA	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.1667
p.V1032F	DO229041	LICA	ICGC	EEPKTPSVPSV	DEG_COP1_1	0.1389
p.V1025I	SIDM00973	Melanoma	GDSC	EEPKTPSVPSV	DEG_COP1_1	0.5965
p.V1025I	SIDM01110	Hepatocellular Carcinoma	GDSC	EEPKTPSVPSV	DEG_COP1_1	0.5965
p.V1025I	SIDM01692	T-Cell Non-Hodgkin's Lymphoma	GDSC	EEPKTPSVPSV	DEG_COP1_1	0.5965
p.V1025I	SIDM01475	Ovarian Carcinoma	GDSC	EEPKTPSVPSV	DEG_COP1_1	0.5965
p.V1025I	SIDM01590	Breast Carcinoma	GDSC	EEPKTPSVPSV	DEG_COP1_1	0.5965

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EEPKTPSVPSV

Degron related mutations and impact score

Drug responses associated with FHDC1 mutations

All proteins holding degron of EEPKTPSVPSV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D6	FH2 domain-containing protein 1	DEG_COP1_1	1015:1025	EEPKTPSVPSV	COP1	0.9733	More...