DegronMD

Uniprot ID: Q9C0D6

Source protein: FH2 domain-containing protein 1

Source gene: FHDC1

Class: DEG_APCC_DBOX_1

Location: 728:736

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9327

ASA_SCORE: 77.0889

COIL: 0.7721

CONS_SCORE: 0.4841

DSS_SCORE: 0.6136

HELIX: 0.1453

FCONS_SCORE: 0.9533

RIG_SCORE: 0.6454

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R729T	TCGA-44-3918	LUAD	TCGA	GRDALGSLS	DEG_APCC_DBOX_1	0.7876
p.R729T	TCGA-UY-A78P	BLCA	TCGA	GRDALGSLS	DEG_APCC_DBOX_1	0.7876
p.R729T	DO48386	BLCA	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	0.7876
p.R729T	DO219036	BLCA	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	0.7876
p.R729T	DO218173	BRCA	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	0.7876
p.R729T	DO23732	LUAD	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	0.7876
p.S734R	TCGA-A5-A0G1	UCEC	TCGA	GRDALGSLS	DEG_APCC_DBOX_1	0.6316
p.S734R	DO42472	UCEC	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	0.6316
p.A738E	DO229213	THCA	ICGC	GRDALGSLS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D6	FH2 domain-containing protein 1	DEG_APCC_DBOX_1	728:736	GRDALGSLS	APC,CDC20,FZR1	0.9327	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons