DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: DEG_SPOP_SBC_1

Location: 2967:2971

E3 ligase: SPOP

DEGRON score: 0.9664

ASA_SCORE: 91.3

COIL: 0.954

CONS_SCORE: 0.3578

DSS_SCORE: 0.6659

HELIX: 0.0318

FCONS_SCORE: 0.9349

RIG_SCORE: 0.6171

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2975C	TCGA-06-0743	GBM	TCGA	PPSST	DEG_SPOP_SBC_1	0.2222
p.R2975C	DO12364	GBM	ICGC	PPSST	DEG_SPOP_SBC_1	0.2222
p.R2966W	TCGA-64-1676	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.3056
p.R2966W	DO23629	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	0.3056
p.R2975H	TCGA-AX-A2HD	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	0.2222
p.R2975H	TCGA-ND-A4WC	UCS	TCGA	PPSST	DEG_SPOP_SBC_1	0.2222
p.R2975H	DO42608	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	0.2222
p.N2977Y	TCGA-D1-A103	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	0.1667
p.N2977Y	DO42312	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	0.1667
p.S2969L	TCGA-EE-A2GL	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	0.8778
p.S2969L	DO37434	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	0.8778
p.L2981V	TCGA-EJ-8468	PRAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.0556
p.L2981V	DO48517	PRAD	ICGC	PPSST	DEG_SPOP_SBC_1	0.0556
p.E2972G	TCGA-F4-6703	COAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.3056
p.E2972G	DO9908	COAD	ICGC	PPSST	DEG_SPOP_SBC_1	0.3056
p.V2964F	TCGA-KN-8422	KICH	TCGA	PPSST	DEG_SPOP_SBC_1	0.25
p.V2964F	DO220449	KICH	ICGC	PPSST	DEG_SPOP_SBC_1	0.25
p.T2971N	DO229018	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	0.7055
p.R2975S	DO229028	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	0.2222
p.N2965T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	0.2778
p.N2965T	ACH-000942	Leukemia	CCLE	PPSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	2967:2971	PPSST	SPOP	0.9664	More...
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	646:650	PPSST	SPOP	0.9933	More...
P15529	Membrane cofactor protein	DEG_SPOP_SBC_1	288:292	PPSST	SPOP	0.9554	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	1220:1224	PPSST	SPOP	0.727	More...
P32243	Homeobox protein OTX2	DEG_SPOP_SBC_1	133:137	PPSST	SPOP	0.9927	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1621:1625	PPSST	SPOP	0.9359	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SPOP_SBC_1	3028:3032	PPSST	SPOP	0.7211	More...
Q02641	Voltage-dependent L-type calcium channel subunit beta-1	DEG_SPOP_SBC_1	414:418	PPSST	SPOP	0.8892	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	735:739	PPSST	SPOP	0.8425	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	1361:1365	PPSST	SPOP	0.9538	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1645:1649	PPSST	SPOP	0.9971	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	915:919	PPSST	SPOP	0.9866	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	24:28	PPSST	SPOP	0.9977	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	500:504	PPSST	SPOP	0.7702	More...
Q86SQ0	Pleckstrin homology-like domain family B member 2	DEG_SPOP_SBC_1	553:557	PPSST	SPOP	0.7645	More...
Q86WP2	Vasculin	DEG_SPOP_SBC_1	16:20	PPSST	SPOP	0.9896	More...
Q8IUC6	TIR domain-containing adapter molecule 1	DEG_SPOP_SBC_1	366:370	PPSST	SPOP	0.9854	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1852:1856	PPSST	SPOP	0.9444	More...
Q8N8W4	Omega-hydroxyceramide transacylase	DEG_SPOP_SBC_1	380:384	PPSST	SPOP	0.9792	More...
Q92793	CREB-binding protein	DEG_SPOP_SBC_1	582:586	PPSST	SPOP	0.9689	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	931:935	PPSST	SPOP	0.8254	More...
Q9H0X9	Oxysterol-binding protein-related protein 5	DEG_SPOP_SBC_1	15:19	PPSST	SPOP	0.9979	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	880:884	PPSST	SPOP	0.9899	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	500:504	PPSST	SPOP	0.8227	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	1673:1677	PPSST	SPOP	0.5462	More...
Q9UJ78	Zinc finger MYM-type protein 5	DEG_SPOP_SBC_1	489:493	PPSST	SPOP	0.8233	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	66:70	PPSST	SPOP	0.9674	More...
Q76G19	PDZ domain-containing protein 4	DEG_SPOP_SBC_1	302:306	PPSST	SPOP	0.8947	More...
Q7L0X2	Glutamate-rich protein 6	DEG_SPOP_SBC_1	126:130	PPSST	SPOP	0.8085	More...
Q5VWI1	Transcription elongation regulator 1-like protein	DEG_SPOP_SBC_1	127:131	PPSST	SPOP	0.9468	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSST

Degron related mutations and impact score

Drug responses associated with KMT2D mutations

All proteins holding degron of PPSST