DegronMD - Q8N8W4(PNPLA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T391P	TCGA-19-5956	GBM	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.25
p.T391P	TCGA-19-5956	GBM	TCGA	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1389
p.P390H	TCGA-49-AAR9	LUAD	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.2778
p.P390H	TCGA-49-AAR9	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1667
p.P381L	TCGA-4Z-AA84	BLCA	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation altering degron motif	0.6471
p.P381L	TCGA-4Z-AA84	BLCA	TCGA	PPSST	DEG_SPOP_SBC_1	380:384	Mutation altering degron motif	0.6471
p.K379R	TCGA-AZ-4315	COAD	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.2778
p.K379R	TCGA-AZ-4315	COAD	TCGA	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.3056
p.P371L	TCGA-BF-AAP2	SKCM	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.0556
p.P371L	TCGA-BF-AAP2	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.0833
p.P392S	TCGA-DU-6407	LGG	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.2222
p.P392S	TCGA-DU-6407	LGG	TCGA	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1111
p.G395R	TCGA-EE-A20C	SKCM	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.1389
p.A388D	DO10647	COAD	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation altering degron motif	0.7793
p.V398I	DO233855	GACA	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.0556
p.V398I	D-392MG	central nervous system	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.0556
p.V389L	DO229028	LICA	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.V389L	DO229028	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.V389L	DO25123	LUAD	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.V389L	DO25123	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.S387I	DO229024	LICA	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation altering degron motif	0.623
p.V389M	DO231708	LINC	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.V389M	DO231708	LINC	ICGC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.Q373H	DO46869	RECA	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.1111
p.Q373H	DO46869	RECA	ICGC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1389
p.H393Y	DO222372	STAD	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.1944
p.H393Y	DO222372	STAD	ICGC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.0833
p.L389P	SIDM00773	Non-Cancerous	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.L389P	SIDM00773	Non-Cancerous	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.L389P	SIDM01126	Small Cell Lung Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.L389P	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.L389P	SIDM00690	Head and Neck Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.L389P	SIDM00690	Head and Neck Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.L389P	SIDM00210	Ovarian Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.L389P	SIDM00210	Ovarian Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.L389P	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.L389P	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.L389P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.L389P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.L389P	SIDM00774	Breast Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.L389P	SIDM00774	Breast Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.L389P	SIDM01173	Rhabdomyosarcoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.L389P	SIDM01173	Rhabdomyosarcoma	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.L389P	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.L389P	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.L389P	SIDM01525	Acute Myeloid Leukemia	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.L389P	SIDM01525	Acute Myeloid Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.V372I	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.0833
p.V372I	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1111
p.V372I	TE-11	oesophagus	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.0833
p.V372I	TE-11	oesophagus	COSMIC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1111
p.S388L	SIDM00149	Melanoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation altering degron motif	0.7667
p.S388L	LOXIMVI	skin	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation altering degron motif	0.7667
p.A376V	SIDM01000	Melanoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.1944
p.A376V	SIDM01000	Melanoma	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.2222
p.A376V	WM-115	skin	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.1944
p.A376V	WM-115	skin	COSMIC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.2222
p.P393T	SIDM01318	Hepatocellular Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.1944
p.P393T	SIDM01318	Hepatocellular Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.0833
p.V389I	D-392MG	central nervous system	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.3056
p.V389I	D-392MG	central nervous system	COSMIC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.A388T	CHP-212	autonomic ganglia	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation altering degron motif	0.7139
p.A379T	CHP-212	autonomic ganglia	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	381:388	Mutation rewiring degron network	0.2778
p.A379T	CHP-212	autonomic ganglia	COSMIC	PPSST	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PNPLA1

UniProt ID: Q8N8W4

Entrez ID: 285848

Protein name: Omega-hydroxyceramide transacylase (EC 2.3.1.296) (Patatin-like phospholipase domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PNPLA1 in