DegronMD

Uniprot ID: Q8N8W4

Source protein: Omega-hydroxyceramide transacylase

Source gene: PNPLA1

Class: DEG_SPOP_SBC_1

Location: 380:384

E3 ligase: SPOP

DEGRON score: 0.9792

ASA_SCORE: 68.88

COIL: 0.9148

CONS_SCORE: 0.2534

DSS_SCORE: 0.6778

HELIX: 0.0146

FCONS_SCORE: 0.9323

RIG_SCORE: 0.4788

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P381L	TCGA-4Z-AA84	BLCA	TCGA	PPSST	DEG_SPOP_SBC_1	0.6471
p.K379R	TCGA-AZ-4315	COAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.3056
p.A379T	CHP-212	autonomic_ganglia	COSMIC	PPSST	DEG_SPOP_SBC_1	0.3056
p.A376V	SIDM01000	Melanoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.2222
p.A376V	WM-115	skin	COSMIC	PPSST	DEG_SPOP_SBC_1	0.2222
p.V389L	DO229028	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	0.1944
p.V389L	DO25123	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	0.1944
p.V389M	DO231708	LINC	ICGC	PPSST	DEG_SPOP_SBC_1	0.1944
p.L389P	SIDM00773	Non-Cancerous	GDSC	PPSST	DEG_SPOP_SBC_1	0.1944
p.L389P	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.1944
p.L389P	SIDM00690	Head and Neck Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.1944
p.L389P	SIDM00210	Ovarian Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.1944
p.L389P	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.1944
p.L389P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	0.1944
p.L389P	SIDM00774	Breast Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.1944
p.L389P	SIDM01173	Rhabdomyosarcoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.1944
p.L389P	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	0.1944
p.L389P	SIDM01525	Acute Myeloid Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	0.1944
p.V389I	D-392MG	central_nervous_system	COSMIC	PPSST	DEG_SPOP_SBC_1	0.1944
p.P390H	TCGA-49-AAR9	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.1667
p.T391P	TCGA-19-5956	GBM	TCGA	PPSST	DEG_SPOP_SBC_1	0.1389
p.Q373H	DO46869	RECA	ICGC	PPSST	DEG_SPOP_SBC_1	0.1389
p.P392S	TCGA-DU-6407	LGG	TCGA	PPSST	DEG_SPOP_SBC_1	0.1111
p.V372I	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.1111
p.V372I	TE-11	oesophagus	COSMIC	PPSST	DEG_SPOP_SBC_1	0.1111

Showing 1 to 25 of 28 entries

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Drug responses associated with PNPLA1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPSST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SPOP_SBC_1	3028:3032	PPSST	SPOP	0.7211	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	880:884	PPSST	SPOP	0.9899	More...
Q92793	CREB-binding protein	DEG_SPOP_SBC_1	582:586	PPSST	SPOP	0.9689	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	66:70	PPSST	SPOP	0.9674	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	931:935	PPSST	SPOP	0.8254	More...
Q7L0X2	Glutamate-rich protein 6	DEG_SPOP_SBC_1	126:130	PPSST	SPOP	0.8085	More...
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	2967:2971	PPSST	SPOP	0.9664	More...
P32243	Homeobox protein OTX2	DEG_SPOP_SBC_1	133:137	PPSST	SPOP	0.9927	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	24:28	PPSST	SPOP	0.9977	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1852:1856	PPSST	SPOP	0.9444	More...
P15529	Membrane cofactor protein	DEG_SPOP_SBC_1	288:292	PPSST	SPOP	0.9554	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1645:1649	PPSST	SPOP	0.9971	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	1220:1224	PPSST	SPOP	0.727	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	500:504	PPSST	SPOP	0.8227	More...
Q8N8W4	Omega-hydroxyceramide transacylase	DEG_SPOP_SBC_1	380:384	PPSST	SPOP	0.9792	More...
Q9H0X9	Oxysterol-binding protein-related protein 5	DEG_SPOP_SBC_1	15:19	PPSST	SPOP	0.9979	More...
Q76G19	PDZ domain-containing protein 4	DEG_SPOP_SBC_1	302:306	PPSST	SPOP	0.8947	More...
Q86SQ0	Pleckstrin homology-like domain family B member 2	DEG_SPOP_SBC_1	553:557	PPSST	SPOP	0.7645	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1621:1625	PPSST	SPOP	0.9359	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	735:739	PPSST	SPOP	0.8425	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	915:919	PPSST	SPOP	0.9866	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	500:504	PPSST	SPOP	0.7702	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	1361:1365	PPSST	SPOP	0.9538	More...
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	646:650	PPSST	SPOP	0.9933	More...
Q8IUC6	TIR domain-containing adapter molecule 1	DEG_SPOP_SBC_1	366:370	PPSST	SPOP	0.9854	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSST

Degron related mutations and impact score

Drug responses associated with PNPLA1 mutations

All proteins holding degron of PPSST