DegronMD - Q9H0X9(OSBPL5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S617N	TCGA-D5-6538	COAD	TCGA	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.2778
p.S617N	DO7784	COAD	ICGC	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.2778
p.P623L	TCGA-EO-A22R	UCEC	TCGA	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation altering degron motif	0.7582
p.P623L	DO42713	UCEC	ICGC	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation altering degron motif	0.7582
p.S624N	TCGA-ER-A197	SKCM	TCGA	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation altering degron motif	0.7069
p.S624N	DO47519	SKCM	ICGC	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation altering degron motif	0.7069
p.R628H	DO227895	COCA	ICGC	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.2778
p.R8W	DO228676	GACA	ICGC	PPSST	DEG_SPOP_SBC_1	15:19	Mutation blocking phosphorylation signal	0.5833
p.P15S	DO233259	GACA	ICGC	PPSST	DEG_SPOP_SBC_1	15:19	Mutation altering degron motif	0.6752
p.Q630K	DO228978	LICA	ICGC	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.2222
p.P15R	DO222775	MELA	ICGC	PPSST	DEG_SPOP_SBC_1	15:19	Mutation altering degron motif	0.7512
p.P20H	DO229275	THCA	ICGC	PPSST	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.3056
p.P20L	DO229211	THCA	ICGC	PPSST	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.3056
p.R8Q	SIDM00984	Other Blood Cancers	GDSC	PPSST	DEG_SPOP_SBC_1	15:19	Mutation blocking phosphorylation signal	0.5833
p.R8Q	BONNA-12	haematopoietic and lymphoid tissue	COSMIC	PPSST	DEG_SPOP_SBC_1	15:19	Mutation blocking phosphorylation signal	0.5833
p.G613V	SIDM00965	Small Cell Lung Carcinoma	GDSC	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.1667
p.G613V	ACH-000800	Lung Cancer	CCLE	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.1667
p.G613V	NCI-H446	lung	COSMIC	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.1667
p.T636M	SIDM00220	Ovarian Carcinoma	GDSC	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.0556
p.T636M	ACH-000962	Ovarian Cancer	CCLE	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.0556
p.T636M	ACH-001145	Ovarian Cancer	CCLE	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.0556
p.T636M	OC-314	ovary	COSMIC	LFWTPSGE	DEG_SCF_FBW7_2	619:626	Mutation rewiring degron network	0.0556
p.A14V	22RV1	prostate	COSMIC	PPSST	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.3056
p.E12K	TALL-1	haematopoietic and lymphoid tissue	COSMIC	PPSST	DEG_SPOP_SBC_1	15:19	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for OSBPL5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OSBPL5

UniProt ID: Q9H0X9

Entrez ID: 114879

Protein name: Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OSBPL5 in