DegronMD

Uniprot ID: Q9H0X9

Source protein: Oxysterol-binding protein-related protein 5

Source gene: OSBPL5

Class: DEG_SCF_FBW7_2

Location: 619:626

E3 ligase: FBXW7

DEGRON score: 0.9705

ASA_SCORE: 48.6125

COIL: 0.5565

CONS_SCORE: 0.5069

DSS_SCORE: 0.3962

HELIX: 0.0719

FCONS_SCORE: 1.0326

RIG_SCORE: 0.7352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S617N	TCGA-D5-6538	COAD	TCGA	LFWTPSGE	DEG_SCF_FBW7_2	0.2778
p.S617N	DO7784	COAD	ICGC	LFWTPSGE	DEG_SCF_FBW7_2	0.2778
p.P623L	TCGA-EO-A22R	UCEC	TCGA	LFWTPSGE	DEG_SCF_FBW7_2	0.7582
p.P623L	DO42713	UCEC	ICGC	LFWTPSGE	DEG_SCF_FBW7_2	0.7582
p.S624N	TCGA-ER-A197	SKCM	TCGA	LFWTPSGE	DEG_SCF_FBW7_2	0.7069
p.S624N	DO47519	SKCM	ICGC	LFWTPSGE	DEG_SCF_FBW7_2	0.7069
p.R628H	DO227895	COCA	ICGC	LFWTPSGE	DEG_SCF_FBW7_2	0.2778
p.Q630K	DO228978	LICA	ICGC	LFWTPSGE	DEG_SCF_FBW7_2	0.2222
p.G613V	SIDM00965	Small Cell Lung Carcinoma	GDSC	LFWTPSGE	DEG_SCF_FBW7_2	0.1667
p.G613V	ACH-000800	Lung Cancer	CCLE	LFWTPSGE	DEG_SCF_FBW7_2	0.1667
p.G613V	NCI-H446	lung	COSMIC	LFWTPSGE	DEG_SCF_FBW7_2	0.1667
p.T636M	SIDM00220	Ovarian Carcinoma	GDSC	LFWTPSGE	DEG_SCF_FBW7_2	0.0556
p.T636M	ACH-000962	Ovarian Cancer	CCLE	LFWTPSGE	DEG_SCF_FBW7_2	0.0556
p.T636M	ACH-001145	Ovarian Cancer	CCLE	LFWTPSGE	DEG_SCF_FBW7_2	0.0556
p.T636M	OC-314	ovary	COSMIC	LFWTPSGE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0X9	Oxysterol-binding protein-related protein 5	DEG_SCF_FBW7_2	619:626	LFWTPSGE	FBXW7	0.9705	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons