DegronMD - Q92793(CREBBP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T915N	TCGA-14-1794	GBM	TCGA	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation rewiring degron network	0.1667
p.P901L	TCGA-A5-A0G2	UCEC	TCGA	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.6471
p.P901L	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.6471
p.P901L	ACH-000315	Lymphoma	CCLE	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.6471
p.P901L	KARPAS-422	haematopoietic and lymphoid tissue	COSMIC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.6471
p.P903H	TCGA-AP-A056	UCEC	TCGA	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.6583
p.P891L	TCGA-AP-A1DK	UCEC	TCGA	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation altering degron motif	0.7582
p.P891L	TCGA-AP-A1DK	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	891:895	Mutation altering degron motif	0.7582
p.E2404K	TCGA-AP-A1DV	UCEC	TCGA	LNTPSRS	DEG_SCF_FBW7_1	2412:2418	Mutation rewiring degron network	0.1111
p.V978M	TCGA-AX-A06F	UCEC	TCGA	SIDNRVPTP	DEG_COP1_1	967:975	Mutation rewiring degron network	0.25
p.T878P	TCGA-AX-A1C5	UCEC	TCGA	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation rewiring degron network	0.0556
p.P583S	TCGA-CR-6481	HNSC	TCGA	PPSST	DEG_SPOP_SBC_1	582:586	Mutation altering degron motif	0.5641
p.G591C	TCGA-D3-A2JC	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.1944
p.G896W	TCGA-D3-A3CE	SKCM	TCGA	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation rewiring degron network	0.2222
p.G896W	TCGA-D3-A3CE	SKCM	TCGA	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation rewiring degron network	0.2778
p.G896W	TCGA-D3-A3CE	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.3056
p.A581D	TCGA-DF-A2KU	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.3056
p.H595R	TCGA-G3-A7M7	LIHC	TCGA	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.0833
p.P960R	TCGA-H7-7774	HNSC	TCGA	SIDNRVPTP	DEG_COP1_1	967:975	Mutation rewiring degron network	0.1389
p.E974K	DO838	BLCA	ICGC	SIDNRVPTP	DEG_COP1_1	967:975	Mutation altering degron motif	0.7022
p.Q910K	DO3095	BRCA	ICGC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation rewiring degron network	0.3056
p.V901M	DO218440	BTCA	ICGC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.7208
p.R587H	DO8119	COAD	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.3056
p.R587H	DO42673	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.3056
p.M984V	DO52450	COCA	ICGC	SIDNRVPTP	DEG_COP1_1	967:975	Mutation rewiring degron network	0.0833
p.R587C	DO48199	ESCA	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.3056
p.R587C	DO38723	STAD	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.3056
p.D971N	DO233219	GACA	ICGC	SIDNRVPTP	DEG_COP1_1	967:975	Mutation altering degron motif	0.6932
p.A581T	DO233837	GACA	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.3056
p.P580T	DO219071	HNSC	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.2778
p.E985K	DO15118	HNSC	ICGC	SIDNRVPTP	DEG_COP1_1	967:975	Mutation rewiring degron network	0.0556
p.P890T	DO229019	LICA	ICGC	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation altering degron motif	0.7031
p.P890T	DO229259	THCA	ICGC	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation altering degron motif	0.7031
p.A581E	DO229028	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.3056
p.S907L	DO229053	LICA	ICGC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.7667
p.P578R	DO26710	LUSC	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.2222
p.P970L	DO222402	MELA	ICGC	SIDNRVPTP	DEG_COP1_1	967:975	Mutation altering degron motif	0.7582
p.P580L	DO222887	MELA	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.2778
p.R586H	DO228138	PBCA	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation altering degron motif	0.8244
p.P890S	DO37659	SKCM	ICGC	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation altering degron motif	0.6752
p.P578S	DO37495	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.2222
p.P895L	DO51274	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	891:895	Mutation altering degron motif	0.7582
p.Q910R	DO38887	STAD	ICGC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation rewiring degron network	0.3056
p.Q905R	DO229229	THCA	ICGC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.7329
p.E2402V	DO40996	UCEC	ICGC	LNTPSRS	DEG_SCF_FBW7_1	2412:2418	Mutation rewiring degron network	0.0556
p.A916T	DO43186	UCEC	ICGC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation rewiring degron network	0.1389
p.P890L	DO52402	UCEC	ICGC	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation altering degron motif	0.7582
p.Q572R	DO41871	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.0556
p.Q910H	DO41235	UCEC	ICGC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation rewiring degron network	0.3056
p.S975P	DO41133	UCEC	ICGC	SIDNRVPTP	DEG_COP1_1	967:975	Mutation altering degron motif	0.6752
p.A2419V	SIDM02059	Colorectal Carcinoma	GDSC	LNTPSRS	DEG_SCF_FBW7_1	2412:2418	Mutation rewiring degron network	0.3056
p.S2421F	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	LNTPSRS	DEG_SCF_FBW7_1	2412:2418	Mutation rewiring degron network	0.25
p.S2421F	ACH-000893	Lung Cancer	CCLE	LNTPSRS	DEG_SCF_FBW7_1	2412:2418	Mutation rewiring degron network	0.25
p.S2421F	NCI-H1651	lung	COSMIC	LNTPSRS	DEG_SCF_FBW7_1	2412:2418	Mutation rewiring degron network	0.25
p.T878A	SIDM01045	Endometrial Carcinoma	GDSC	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation rewiring degron network	0.0556
p.T878A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation rewiring degron network	0.0556
p.T878A	EN	endometrium	COSMIC	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation rewiring degron network	0.0556
p.T900S	SIDM00056	Thyroid Gland Carcinoma	GDSC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.6005
p.T900S	ACH-002148	Thyroid Cancer	CCLE	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.6005
p.T900S	K5	thyroid	COSMIC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation altering degron motif	0.6005
p.T573A	SIDM00839	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.0833
p.T573A	ACH-000950	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.0833
p.T573A	LoVo	large intestine	COSMIC	PPSST	DEG_SPOP_SBC_1	582:586	Mutation rewiring degron network	0.0833
p.P975L	SIDM01706	Hodgkin's Lymphoma	GDSC	SIDNRVPTP	DEG_COP1_1	967:975	Mutation altering degron motif	0.6471
p.P975L	ACH-001093	Non-Cancerous	CCLE	SIDNRVPTP	DEG_COP1_1	967:975	Mutation altering degron motif	0.6471
p.P960T	ACH-001563	Skin Cancer	CCLE	SIDNRVPTP	DEG_COP1_1	967:975	Mutation rewiring degron network	0.1389
p.P911L	GP5d	large intestine	COSMIC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation rewiring degron network	0.2778
p.A883V	EPLC-272H	lung	COSMIC	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation rewiring degron network	0.1944
p.A883V	EPLC-272H	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.1111
p.T961M	SK-UT-1	soft tissue	COSMIC	SIDNRVPTP	DEG_COP1_1	967:975	Mutation rewiring degron network	0.1667
p.P899S	CP66-MEL	skin	COSMIC	TPTPGSVPSA	DEG_COP1_1	900:909	Mutation rewiring degron network	0.3056
p.P899S	CP66-MEL	skin	COSMIC	PSTPVSS	DEG_SCF_FBW7_1	888:894	Mutation rewiring degron network	0.1944
p.P899S	CP66-MEL	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.2222
p.D971Y	BICR22	upper aerodigestive tract	COSMIC	SIDNRVPTP	DEG_COP1_1	967:975	Mutation altering degron motif	0.7325

Kaplan plot for CREBBP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CREBBP

UniProt ID: Q92793

Entrez ID: 1387

Protein name: CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CREBBP in