DegronMD

Uniprot ID: Q92793

Source protein: CREB-binding protein

Source gene: CREBBP

Class: DEG_COP1_1

Location: 967:975

E3 ligase: COP1

DEGRON score: 0.7528

ASA_SCORE: 97.5778

COIL: 0.9034

CONS_SCORE: 0.3643

DSS_SCORE: 0.6802

HELIX: 0.0784

FCONS_SCORE: 1.1585

RIG_SCORE: 0.6278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V978M	TCGA-AX-A06F	UCEC	TCGA	SIDNRVPTP	DEG_COP1_1	0.25
p.P960R	TCGA-H7-7774	HNSC	TCGA	SIDNRVPTP	DEG_COP1_1	0.1389
p.E974K	DO838	BLCA	ICGC	SIDNRVPTP	DEG_COP1_1	0.7022
p.M984V	DO52450	COCA	ICGC	SIDNRVPTP	DEG_COP1_1	0.0833
p.D971N	DO233219	GACA	ICGC	SIDNRVPTP	DEG_COP1_1	0.6932
p.E985K	DO15118	HNSC	ICGC	SIDNRVPTP	DEG_COP1_1	0.0556
p.P970L	DO222402	MELA	ICGC	SIDNRVPTP	DEG_COP1_1	0.7582
p.S975P	DO41133	UCEC	ICGC	SIDNRVPTP	DEG_COP1_1	0.6752
p.P975L	SIDM01706	Hodgkin's Lymphoma	GDSC	SIDNRVPTP	DEG_COP1_1	0.6471
p.P975L	ACH-001093	Non-Cancerous	CCLE	SIDNRVPTP	DEG_COP1_1	0.6471
p.P960T	ACH-001563	Skin Cancer	CCLE	SIDNRVPTP	DEG_COP1_1	0.1389
p.T961M	SK-UT-1	soft_tissue	COSMIC	SIDNRVPTP	DEG_COP1_1	0.1667
p.D971Y	BICR22	upper_aerodigestive_tract	COSMIC	SIDNRVPTP	DEG_COP1_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92793	CREB-binding protein	DEG_COP1_1	967:975	SIDNRVPTP	COP1	0.7528	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons