DegronMD

Uniprot ID: Q92793

Source protein: CREB-binding protein

Source gene: CREBBP

Class: DEG_SCF_FBW7_1

Location: 888:894

E3 ligase: FBXW7

DEGRON score: 0.9858

ASA_SCORE: 85.9571

COIL: 0.954

CONS_SCORE: 0.3713

DSS_SCORE: 0.8429

HELIX: 0.0241

FCONS_SCORE: 1.1057

RIG_SCORE: 0.5153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P891L	TCGA-AP-A1DK	UCEC	TCGA	PSTPVSS	DEG_SCF_FBW7_1	0.7582
p.T878P	TCGA-AX-A1C5	UCEC	TCGA	PSTPVSS	DEG_SCF_FBW7_1	0.0556
p.G896W	TCGA-D3-A3CE	SKCM	TCGA	PSTPVSS	DEG_SCF_FBW7_1	0.2778
p.P890T	DO229019	LICA	ICGC	PSTPVSS	DEG_SCF_FBW7_1	0.7031
p.P890T	DO229259	THCA	ICGC	PSTPVSS	DEG_SCF_FBW7_1	0.7031
p.P890S	DO37659	SKCM	ICGC	PSTPVSS	DEG_SCF_FBW7_1	0.6752
p.P890L	DO52402	UCEC	ICGC	PSTPVSS	DEG_SCF_FBW7_1	0.7582
p.T878A	SIDM01045	Endometrial Carcinoma	GDSC	PSTPVSS	DEG_SCF_FBW7_1	0.0556
p.T878A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PSTPVSS	DEG_SCF_FBW7_1	0.0556
p.T878A	EN	endometrium	COSMIC	PSTPVSS	DEG_SCF_FBW7_1	0.0556
p.A883V	EPLC-272H	lung	COSMIC	PSTPVSS	DEG_SCF_FBW7_1	0.1944
p.P899S	CP66-MEL	skin	COSMIC	PSTPVSS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92793	CREB-binding protein	DEG_SCF_FBW7_1	888:894	PSTPVSS	FBXW7	0.9858	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons