DegronMD

Uniprot ID: Q92793

Source protein: CREB-binding protein

Source gene: CREBBP

Class: DEG_COP1_1

Location: 900:909

E3 ligase: COP1

DEGRON score: 0.9658

ASA_SCORE: 93.78

COIL: 0.9729

CONS_SCORE: 0.3655

DSS_SCORE: 0.7943

HELIX: 0.0122

FCONS_SCORE: 1.0677

RIG_SCORE: 0.534

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S907L	DO229053	LICA	ICGC	TPTPGSVPSA	DEG_COP1_1	0.7667
p.Q905R	DO229229	THCA	ICGC	TPTPGSVPSA	DEG_COP1_1	0.7329
p.V901M	DO218440	BTCA	ICGC	TPTPGSVPSA	DEG_COP1_1	0.7208
p.P903H	TCGA-AP-A056	UCEC	TCGA	TPTPGSVPSA	DEG_COP1_1	0.6583
p.P901L	TCGA-A5-A0G2	UCEC	TCGA	TPTPGSVPSA	DEG_COP1_1	0.6471
p.P901L	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	TPTPGSVPSA	DEG_COP1_1	0.6471
p.P901L	ACH-000315	Lymphoma	CCLE	TPTPGSVPSA	DEG_COP1_1	0.6471
p.P901L	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	TPTPGSVPSA	DEG_COP1_1	0.6471
p.T900S	SIDM00056	Thyroid Gland Carcinoma	GDSC	TPTPGSVPSA	DEG_COP1_1	0.6005
p.T900S	ACH-002148	Thyroid Cancer	CCLE	TPTPGSVPSA	DEG_COP1_1	0.6005
p.T900S	K5	thyroid	COSMIC	TPTPGSVPSA	DEG_COP1_1	0.6005
p.Q910K	DO3095	BRCA	ICGC	TPTPGSVPSA	DEG_COP1_1	0.3056
p.Q910R	DO38887	STAD	ICGC	TPTPGSVPSA	DEG_COP1_1	0.3056
p.Q910H	DO41235	UCEC	ICGC	TPTPGSVPSA	DEG_COP1_1	0.3056
p.P899S	CP66-MEL	skin	COSMIC	TPTPGSVPSA	DEG_COP1_1	0.3056
p.P911L	GP5d	large_intestine	COSMIC	TPTPGSVPSA	DEG_COP1_1	0.2778
p.G896W	TCGA-D3-A3CE	SKCM	TCGA	TPTPGSVPSA	DEG_COP1_1	0.2222
p.T915N	TCGA-14-1794	GBM	TCGA	TPTPGSVPSA	DEG_COP1_1	0.1667
p.A916T	DO43186	UCEC	ICGC	TPTPGSVPSA	DEG_COP1_1	0.1389

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92793	CREB-binding protein	DEG_COP1_1	900:909	TPTPGSVPSA	COP1	0.9658	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons