DegronMD

Uniprot ID: Q92793

Source protein: CREB-binding protein

Source gene: CREBBP

Class: DEG_SCF_FBW7_1

Location: 2412:2418

E3 ligase: FBXW7

DEGRON score: 0.9726

ASA_SCORE: 89.7286

COIL: 0.8663

CONS_SCORE: 0.3266

DSS_SCORE: 0.5378

HELIX: 0.1096

FCONS_SCORE: 1.0135

RIG_SCORE: 0.6671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2404K	TCGA-AP-A1DV	UCEC	TCGA	LNTPSRS	DEG_SCF_FBW7_1	0.1111
p.E2402V	DO40996	UCEC	ICGC	LNTPSRS	DEG_SCF_FBW7_1	0.0556
p.A2419V	SIDM02059	Colorectal Carcinoma	GDSC	LNTPSRS	DEG_SCF_FBW7_1	0.3056
p.S2421F	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	LNTPSRS	DEG_SCF_FBW7_1	0.25
p.S2421F	ACH-000893	Lung Cancer	CCLE	LNTPSRS	DEG_SCF_FBW7_1	0.25
p.S2421F	NCI-H1651	lung	COSMIC	LNTPSRS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92793	CREB-binding protein	DEG_SCF_FBW7_1	2412:2418	LNTPSRS	FBXW7	0.9726	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons