DegronMD - Q7Z3B3(KANSL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H572N	TCGA-13-1477	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.H572N	DO27978	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.V754G	TCGA-50-6590	LUAD	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.7532
p.V754G	DO24692	LUAD	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.7532
p.V754L	TCGA-50-6590	LUAD	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.5654
p.V754L	DO24692	LUAD	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.5654
p.V754L	DO229257	THCA	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.5654
p.E35K	TCGA-55-6968	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1389
p.E35K	TCGA-AN-A046	BRCA	TCGA	PPSST	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1389
p.E35K	DO1285	BRCA	ICGC	PPSST	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1389
p.E35K	DO222798	COCA	ICGC	PPSST	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1389
p.E35K	DO23759	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1389
p.V757L	TCGA-56-7222	LUSC	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.2778
p.V757L	DO26842	LUSC	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.2778
p.Q848L	TCGA-58-8388	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0833
p.S839I	TCGA-AA-A00N	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.7341
p.S839I	DO9876	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.7341
p.S847L	TCGA-AG-A002	READ	TCGA	PASSS	DEG_SPOP_SBC_1	835:839	Mutation blocking phosphorylation signal	0.5556
p.S845N	TCGA-B5-A1MX	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1667
p.S845N	DO41999	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1667
p.S737P	TCGA-CM-5861	COAD	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.0556
p.S737P	DO7918	COAD	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.0556
p.R592Q	TCGA-CM-6162	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.R592Q	DO8479	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.R592Q	DO52675	MALY	ICGC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.R592Q	DO32869	PACA	ICGC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.S186F	TCGA-D9-A4Z3	SKCM	TCGA	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.9093
p.S186F	DO222880	MELA	ICGC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.9093
p.S186F	DO47555	SKCM	ICGC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.9093
p.R592W	TCGA-E6-A2P8	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.R592W	DO40924	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.H747N	TCGA-EE-A2GT	SKCM	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.6312
p.H747N	DO37946	SKCM	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.6312
p.F20L	TCGA-EK-A2PG	CESC	TCGA	PPSST	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2222
p.F20L	DO49939	CESC	ICGC	PPSST	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2222
p.P758S	TCGA-EO-A22R	UCEC	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.25
p.P758S	DO229213	THCA	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.25
p.P758S	DO42713	UCEC	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.25
p.R742W	TCGA-EO-A22R	UCEC	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.1944
p.R742W	DO42713	UCEC	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.1944
p.R742W	SIDM00402	Bladder Carcinoma	GDSC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.1944
p.R742W	ACH-000473	Bladder Cancer	CCLE	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.1944
p.R742W	RT-112	urinary tract	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.1944
p.V580I	TCGA-EO-A22R	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation altering degron motif	0.7076
p.V580I	DO42713	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation altering degron motif	0.7076
p.V580I	SIDM00302	Other Solid Cancers	GDSC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation altering degron motif	0.7076
p.V580I	SIDM01612	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation altering degron motif	0.7076
p.V580I	SIDM00173	Head and Neck Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation altering degron motif	0.7076
p.H750Y	TCGA-IA-A83V	KIRP	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.6118
p.H750Y	DO219692	KIRP	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.6118
p.A182T	TCGA-L5-A4OI	ESCA	TCGA	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7139
p.V589L	DO222563	BTCA	ICGC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1944
p.T828I	DO233854	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation blocking phosphorylation signal	0.5833
p.P25T	DO233864	GACA	ICGC	PPSST	DEG_SPOP_SBC_1	24:28	Mutation altering degron motif	0.5919
p.H572R	DO23260	LINC	ICGC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation rewiring degron network	0.1111
p.S581T	DO231786	LINC	ICGC	VSSSS	DEG_SPOP_SBC_1	580:584	Mutation altering degron motif	0.6005
p.S837N	DO50692	ORCA	ICGC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.7069
p.A182S	SIDM00845	Burkitt's Lymphoma	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7588
p.A182S	SIDM01519	Head and Neck Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7588
p.A182S	Daudi	haematopoietic and lymphoid tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7588
p.T174S	SIDM00845	Burkitt's Lymphoma	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation blocking phosphorylation signal	0.5556
p.T174S	SIDM00461	Acute Myeloid Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation blocking phosphorylation signal	0.5556
p.T174S	SIDM01519	Head and Neck Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation blocking phosphorylation signal	0.5556
p.T174S	ACH-000786	Lymphoma	CCLE	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation blocking phosphorylation signal	0.5556
p.T174S	Daudi	haematopoietic and lymphoid tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation blocking phosphorylation signal	0.5556
p.M193T	SIDM00041	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.1389
p.M193T	ACH-002306	Gastric Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.1389
p.M193T	STS-0421	soft tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.1389
p.H189R	SIDM01638	Non-Cancerous	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.25
p.H189R	SIDM00172	Head and Neck Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.25
p.H189R	ACH-002212	Head and Neck Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.25
p.H189R	ACH-002342	Non-Cancerous	CCLE	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.25
p.R748W	SIDM00446	Acute Myeloid Leukemia	GDSC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.8634
p.R748W	ACH-000113	Leukemia	CCLE	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.8634
p.R748W	OCI-AML2	haematopoietic and lymphoid tissue	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation altering degron motif	0.8634
p.S173F	SIDM00190	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation blocking phosphorylation signal	0.5278
p.S173F	CP66-MEL	skin	COSMIC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation blocking phosphorylation signal	0.5278
p.G32A	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2222
p.G32A	ACH-000853	Lung Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2222
p.G32A	NCI-H661	lung	COSMIC	PPSST	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2222
p.T843I	SIDM01218	Other Solid Cancers	GDSC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.2222
p.T843I	JEG-3	placenta	COSMIC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.2222
p.R181Q	SIDM00013	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.3056
p.R181Q	ACH-002387	Skin Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.3056
p.Q825H	SIDM00383	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0556
p.Q825H	SCH	stomach	COSMIC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0556
p.Q825L	SIDM00383	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0556
p.Q825L	SCH	stomach	COSMIC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0556
p.D744H	SIDM00604	Oral Cavity Carcinoma	GDSC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.25
p.D744H	KON	upper aerodigestive tract	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.25
p.G179E	SIDM00780	Colorectal Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.25
p.Q849L	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0556
p.T765A	ACH-000961	Endometrial/Uterine Cancer	CCLE	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.0556
p.R827Q	ACH-000979	Prostate Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	835:839	Mutation blocking phosphorylation signal	0.5556
p.R827Q	DU-145	prostate	COSMIC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation blocking phosphorylation signal	0.5556
p.V829A	ACH-002166	Skin Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	835:839	Mutation blocking phosphorylation signal	0.6111
p.V829A	MZ7-mel	skin	COSMIC	PASSS	DEG_SPOP_SBC_1	835:839	Mutation blocking phosphorylation signal	0.6111
p.Q762H	ACH-002198	Gastric Cancer	CCLE	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.1389
p.Q762H	SCH	stomach	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.1389
p.Q762L	ACH-002198	Gastric Cancer	CCLE	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.1389
p.Q762L	SCH	stomach	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.1389
p.M742T	5637	urinary tract	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	747:755	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KANSL1

UniProt ID: Q7Z3B3

Entrez ID: 284058

Protein name: KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KANSL1 in