DegronMD

Uniprot ID: Q7Z3B3

Source protein: KAT8 regulatory NSL complex subunit 1

Source gene: KANSL1

Class: DEG_APCC_DBOX_1

Location: 747:755

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5778

ASA_SCORE: 88.4556

COIL: 0.6952

CONS_SCORE: 0.3078

DSS_SCORE: 0.6457

HELIX: 0.2684

FCONS_SCORE: 1.0205

RIG_SCORE: 0.6984

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V754G	TCGA-50-6590	LUAD	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	0.7532
p.V754G	DO24692	LUAD	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	0.7532
p.V754L	TCGA-50-6590	LUAD	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	0.5654
p.V754L	DO24692	LUAD	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	0.5654
p.V754L	DO229257	THCA	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	0.5654
p.V757L	TCGA-56-7222	LUSC	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	0.2778
p.V757L	DO26842	LUSC	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	0.2778
p.S737P	TCGA-CM-5861	COAD	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	0.0556
p.S737P	DO7918	COAD	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	0.0556
p.H747N	TCGA-EE-A2GT	SKCM	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	0.6312
p.H747N	DO37946	SKCM	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	0.6312
p.P758S	TCGA-EO-A22R	UCEC	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	0.25
p.P758S	DO229213	THCA	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	0.25
p.P758S	DO42713	UCEC	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	0.25
p.R742W	TCGA-EO-A22R	UCEC	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	0.1944
p.R742W	DO42713	UCEC	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	0.1944
p.R742W	SIDM00402	Bladder Carcinoma	GDSC	HRQHLDDVG	DEG_APCC_DBOX_1	0.1944
p.R742W	ACH-000473	Bladder Cancer	CCLE	HRQHLDDVG	DEG_APCC_DBOX_1	0.1944
p.R742W	RT-112	urinary_tract	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	0.1944
p.H750Y	TCGA-IA-A83V	KIRP	TCGA	HRQHLDDVG	DEG_APCC_DBOX_1	0.6118
p.H750Y	DO219692	KIRP	ICGC	HRQHLDDVG	DEG_APCC_DBOX_1	0.6118
p.R748W	SIDM00446	Acute Myeloid Leukemia	GDSC	HRQHLDDVG	DEG_APCC_DBOX_1	0.8634
p.R748W	ACH-000113	Leukemia	CCLE	HRQHLDDVG	DEG_APCC_DBOX_1	0.8634
p.R748W	OCI-AML2	haematopoietic_and_lymphoid_tissue	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	0.8634
p.D744H	SIDM00604	Oral Cavity Carcinoma	GDSC	HRQHLDDVG	DEG_APCC_DBOX_1	0.25
p.D744H	KON	upper_aerodigestive_tract	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	0.25
p.T765A	ACH-000961	Endometrial/Uterine Cancer	CCLE	HRQHLDDVG	DEG_APCC_DBOX_1	0.0556
p.Q762H	ACH-002198	Gastric Cancer	CCLE	HRQHLDDVG	DEG_APCC_DBOX_1	0.1389
p.Q762H	SCH	stomach	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	0.1389
p.Q762L	ACH-002198	Gastric Cancer	CCLE	HRQHLDDVG	DEG_APCC_DBOX_1	0.1389
p.Q762L	SCH	stomach	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	0.1389
p.M742T	5637	urinary_tract	COSMIC	HRQHLDDVG	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HRQHLDDVG

Degron related mutations and impact score

Drug responses associated with KANSL1 mutations

All proteins holding degron of HRQHLDDVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_APCC_DBOX_1	747:755	HRQHLDDVG	APC,CDC20,FZR1	0.5778	More...