DegronMD

Uniprot ID: Q7Z3B3

Source protein: KAT8 regulatory NSL complex subunit 1

Source gene: KANSL1

Class: DEG_SPOP_SBC_1

Location: 182:186

E3 ligase: SPOP

DEGRON score: 0.8556

ASA_SCORE: 69.34

COIL: 0.727

CONS_SCORE: 0.3135

DSS_SCORE: 0.6027

HELIX: 0.2176

FCONS_SCORE: 0.96

RIG_SCORE: 0.679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S186F	TCGA-D9-A4Z3	SKCM	TCGA	ALTSS	DEG_SPOP_SBC_1	0.9093
p.S186F	DO222880	MELA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.9093
p.S186F	DO47555	SKCM	ICGC	ALTSS	DEG_SPOP_SBC_1	0.9093
p.A182T	TCGA-L5-A4OI	ESCA	TCGA	ALTSS	DEG_SPOP_SBC_1	0.7139
p.A182S	SIDM00845	Burkitt's Lymphoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.7588
p.A182S	SIDM01519	Head and Neck Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.7588
p.A182S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.7588
p.T174S	SIDM00845	Burkitt's Lymphoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.5556
p.T174S	SIDM00461	Acute Myeloid Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.5556
p.T174S	SIDM01519	Head and Neck Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.5556
p.T174S	ACH-000786	Lymphoma	CCLE	ALTSS	DEG_SPOP_SBC_1	0.5556
p.T174S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.5556
p.M193T	SIDM00041	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.M193T	ACH-002306	Gastric Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.1389
p.M193T	STS-0421	soft_tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.H189R	SIDM01638	Non-Cancerous	GDSC	ALTSS	DEG_SPOP_SBC_1	0.25
p.H189R	SIDM00172	Head and Neck Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.25
p.H189R	ACH-002212	Head and Neck Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.25
p.H189R	ACH-002342	Non-Cancerous	CCLE	ALTSS	DEG_SPOP_SBC_1	0.25
p.S173F	SIDM00190	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.5278
p.S173F	CP66-MEL	skin	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.5278
p.R181Q	SIDM00013	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.3056
p.R181Q	ACH-002387	Skin Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.3056
p.G179E	SIDM00780	Colorectal Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	288:292	ALTSS	SPOP	0.9872	More...
P40305	Interferon alpha-inducible protein 27, mitochondrial	DEG_SPOP_SBC_1	5:9	ALTSS	SPOP	0.8417	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	37:41	ALTSS	SPOP	0.9991	More...
Q5JS13	Ras-specific guanine nucleotide-releasing factor RalGPS1	DEG_SPOP_SBC_1	385:389	ALTSS	SPOP	0.7353	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	1299:1303	ALTSS	SPOP	0.9456	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	182:186	ALTSS	SPOP	0.8556	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	382:386	ALTSS	SPOP	0.8748	More...
Q9NZ09	Ubiquitin-associated protein 1	DEG_SPOP_SBC_1	334:338	ALTSS	SPOP	0.9693	More...
Q6TFL3	Coiled-coil domain-containing protein 171	DEG_SPOP_SBC_1	1303:1307	ALTSS	SPOP	0.6534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALTSS

Degron related mutations and impact score

Drug responses associated with KANSL1 mutations

All proteins holding degron of ALTSS