DegronMD

Uniprot ID: Q6TFL3

Source protein: Coiled-coil domain-containing protein 171

Source gene: CCDC171

Class: DEG_SPOP_SBC_1

Location: 1303:1307

E3 ligase: SPOP

DEGRON score: 0.6534

ASA_SCORE: 82.92

COIL: 0.866

CONS_SCORE: 0.2223

DSS_SCORE: 0.3726

HELIX: 0.0894

FCONS_SCORE: 0.9396

RIG_SCORE: 0.6933

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1315P	TCGA-AX-A06F	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	0.5556
p.S1315P	DO41752	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.5556
p.T1295I	DO233764	GACA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1111
p.A1316G	DO50861	LICA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.0833
p.S1310A	SIDM01199	Hepatocellular Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.25
p.S1310A	ACH-000493	Liver Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.25
p.S1310A	SNU-423	liver	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.25
p.S1310F	SIDM01135	Pancreatic Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.25
p.S1310F	ACH-000060	Pancreatic Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.25
p.S1310F	PANC-10-05	pancreas	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	288:292	ALTSS	SPOP	0.9872	More...
P40305	Interferon alpha-inducible protein 27, mitochondrial	DEG_SPOP_SBC_1	5:9	ALTSS	SPOP	0.8417	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	37:41	ALTSS	SPOP	0.9991	More...
Q5JS13	Ras-specific guanine nucleotide-releasing factor RalGPS1	DEG_SPOP_SBC_1	385:389	ALTSS	SPOP	0.7353	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	1299:1303	ALTSS	SPOP	0.9456	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	182:186	ALTSS	SPOP	0.8556	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	382:386	ALTSS	SPOP	0.8748	More...
Q9NZ09	Ubiquitin-associated protein 1	DEG_SPOP_SBC_1	334:338	ALTSS	SPOP	0.9693	More...
Q6TFL3	Coiled-coil domain-containing protein 171	DEG_SPOP_SBC_1	1303:1307	ALTSS	SPOP	0.6534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons