DegronMD - Q6TFL3(CCDC171)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1315P	TCGA-AX-A06F	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	1303:1307	Mutation blocking phosphorylation signal	0.5556
p.S1315P	DO41752	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	1303:1307	Mutation blocking phosphorylation signal	0.5556
p.T1295I	DO233764	GACA	ICGC	ALTSS	DEG_SPOP_SBC_1	1303:1307	Mutation rewiring degron network	0.1111
p.A1316G	DO50861	LICA	ICGC	ALTSS	DEG_SPOP_SBC_1	1303:1307	Mutation rewiring degron network	0.0833
p.S1310A	SIDM01199	Hepatocellular Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	1303:1307	Mutation rewiring degron network	0.25
p.S1310A	ACH-000493	Liver Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	1303:1307	Mutation rewiring degron network	0.25
p.S1310A	SNU-423	liver	COSMIC	ALTSS	DEG_SPOP_SBC_1	1303:1307	Mutation rewiring degron network	0.25
p.S1310F	SIDM01135	Pancreatic Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	1303:1307	Mutation rewiring degron network	0.25
p.S1310F	ACH-000060	Pancreatic Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	1303:1307	Mutation rewiring degron network	0.25
p.S1310F	PANC-10-05	pancreas	COSMIC	ALTSS	DEG_SPOP_SBC_1	1303:1307	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons