DegronMD

Uniprot ID: Q9NZ09

Source protein: Ubiquitin-associated protein 1

Source gene: UBAP1

Class: DEG_SPOP_SBC_1

Location: 334:338

E3 ligase: SPOP

DEGRON score: 0.9693

ASA_SCORE: 67.64

COIL: 0.7314

CONS_SCORE: 0.3356

DSS_SCORE: 0.538

HELIX: 0.2354

FCONS_SCORE: 1.0365

RIG_SCORE: 0.6988

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A348V	TCGA-66-2768	LUSC	TCGA	ALTSS	DEG_SPOP_SBC_1	0.0556
p.A345S	TCGA-AX-A06F	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	0.1389
p.L330M	TCGA-L5-A43J	ESCA	TCGA	ALTSS	DEG_SPOP_SBC_1	0.2222
p.D327G	DO8264	COAD	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.S344T	DO234180	ESAD	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1667
p.S347C	DO26404	LUAD	ICGC	ALTSS	DEG_SPOP_SBC_1	0.0833
p.S344C	DO23786	LUAD	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1667
p.S344C	DO45349	LUAD	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1667
p.E331K	DO223286	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.25
p.A345V	SIDM00845	Burkitt's Lymphoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.A345V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.I327M	SIDM00898	Breast Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.I327M	AU565	breast	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.L335P	SIDM00567	Other Solid Cancers	GDSC	ALTSS	DEG_SPOP_SBC_1	0.6471
p.L335P	ONS-76	central_nervous_system	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.6471
p.N326S	SIDM00989	Bladder Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.1111
p.N326S	BFTC-905	urinary_tract	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.1111
p.N341K	SIDM01772	Mesothelioma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.25
p.Q339K	ACH-000571	Brain Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	288:292	ALTSS	SPOP	0.9872	More...
P40305	Interferon alpha-inducible protein 27, mitochondrial	DEG_SPOP_SBC_1	5:9	ALTSS	SPOP	0.8417	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	37:41	ALTSS	SPOP	0.9991	More...
Q5JS13	Ras-specific guanine nucleotide-releasing factor RalGPS1	DEG_SPOP_SBC_1	385:389	ALTSS	SPOP	0.7353	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	1299:1303	ALTSS	SPOP	0.9456	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	182:186	ALTSS	SPOP	0.8556	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	382:386	ALTSS	SPOP	0.8748	More...
Q9NZ09	Ubiquitin-associated protein 1	DEG_SPOP_SBC_1	334:338	ALTSS	SPOP	0.9693	More...
Q6TFL3	Coiled-coil domain-containing protein 171	DEG_SPOP_SBC_1	1303:1307	ALTSS	SPOP	0.6534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons