DegronMD

Uniprot ID: Q5JS13

Source protein: Ras-specific guanine nucleotide-releasing factor RalGPS1

Source gene: RALGPS1

Class: DEG_SPOP_SBC_1

Location: 385:389

E3 ligase: SPOP

DEGRON score: 0.7353

ASA_SCORE: 81.34

COIL: 0.88

CONS_SCORE: 0.3975

DSS_SCORE: 0.504

HELIX: 0.0868

FCONS_SCORE: 0.9316

RIG_SCORE: 0.678

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R381Q	TCGA-2F-A9KO	BLCA	TCGA	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R381Q	TCGA-DK-A1A3	BLCA	TCGA	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R381Q	TCGA-GV-A3JZ	BLCA	TCGA	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R381Q	DO51859	BLCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R381Q	DO558	BLCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R381Q	DO773	BLCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R381Q	DO225258	BRCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R381Q	SIDM01750	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R381Q	ACH-000801	Skin Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R378C	TCGA-A5-A1OF	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	0.1389
p.R378C	DO42568	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.R378C	SIDM00850	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.R378C	AGS	stomach	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.L396F	TCGA-EB-A24D	SKCM	TCGA	ALTSS	DEG_SPOP_SBC_1	0.1389
p.L396F	DO37440	SKCM	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.S388F	TCGA-EE-A3J5	SKCM	TCGA	ALTSS	DEG_SPOP_SBC_1	0.7982
p.S388F	DO47331	SKCM	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7982
p.R398T	DO48442	BLCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.0833
p.G383C	DO229010	COCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00216	Colorectal Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00437	Acute Myeloid Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00340	Plasma Cell Myeloma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00232	Kidney Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00602	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00496	Thyroid Gland Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00370	T-Lymphoblastic Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00463	T-Lymphoblastic Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00263	Ewing's Sarcoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01242	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00581	Glioblastoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00002	Neuroblastoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00571	Pancreatic Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00060	Ovarian Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00568	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00282	Colorectal Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00687	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00235	Kidney Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00596	Endometrial Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01045	Endometrial Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00817	Kidney Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00252	Biliary Tract Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00149	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00299	Other Sarcomas	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00410	Other Blood Cancers	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00214	Colorectal Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00247	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01653	Non-Cancerous	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00207	Glioblastoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01257	Hepatocellular Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00380	Acute Myeloid Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00579	Neuroblastoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00543	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00996	Thyroid Gland Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00045	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00243	Other Solid Cancers	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01033	Bladder Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00192	Colorectal Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01617	Endometrial Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00168	Head and Neck Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01470	Acute Myeloid Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01460	Glioma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01781	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00062	Hepatocellular Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01336	Glioblastoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01494	Glioblastoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01413	Oral Cavity Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00016	Neuroblastoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01574	Plasma Cell Myeloma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01442	Glioma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00162	Biliary Tract Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01434	Hepatocellular Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01729	Endometrial Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01443	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.N385S	DO233913	GACA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7069
p.A385S	DO228948	LICA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7588
p.P378T	DO50278	SKCM	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.P378L	DO52409	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.P378L	HCT-116	large_intestine	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.R382K	SIDM00780	Colorectal Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.25
p.S389P	ACH-000940	Endometrial/Uterine Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.6752
p.S389P	AN3-CA	endometrium	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.6752
p.R381S	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.P375H	NCI-H630	large_intestine	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.0556
p.I383V	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	288:292	ALTSS	SPOP	0.9872	More...
P40305	Interferon alpha-inducible protein 27, mitochondrial	DEG_SPOP_SBC_1	5:9	ALTSS	SPOP	0.8417	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	37:41	ALTSS	SPOP	0.9991	More...
Q5JS13	Ras-specific guanine nucleotide-releasing factor RalGPS1	DEG_SPOP_SBC_1	385:389	ALTSS	SPOP	0.7353	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	1299:1303	ALTSS	SPOP	0.9456	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	182:186	ALTSS	SPOP	0.8556	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	382:386	ALTSS	SPOP	0.8748	More...
Q9NZ09	Ubiquitin-associated protein 1	DEG_SPOP_SBC_1	334:338	ALTSS	SPOP	0.9693	More...
Q6TFL3	Coiled-coil domain-containing protein 171	DEG_SPOP_SBC_1	1303:1307	ALTSS	SPOP	0.6534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALTSS

Degron related mutations and impact score

Drug responses associated with RALGPS1 mutations

All proteins holding degron of ALTSS