DegronMD

Uniprot ID: Q5JS13

Source protein: Ras-specific guanine nucleotide-releasing factor RalGPS1

Source gene: RALGPS1

Class: DEG_SPOP_SBC_1

Location: 385:389

E3 ligase: SPOP

DEGRON score: 0.7353

ASA_SCORE: 81.34

COIL: 0.88

CONS_SCORE: 0.3975

DSS_SCORE: 0.504

HELIX: 0.0868

FCONS_SCORE: 0.9316

RIG_SCORE: 0.678

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S388F	TCGA-EE-A3J5	SKCM	TCGA	ALTSS	DEG_SPOP_SBC_1	0.7982
p.S388F	DO47331	SKCM	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7982
p.A385S	DO228948	LICA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7588
p.N385S	DO233913	GACA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7069
p.S389P	ACH-000940	Endometrial/Uterine Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.6752
p.S389P	AN3-CA	endometrium	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.6752
p.G383C	DO229010	COCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00216	Colorectal Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00437	Acute Myeloid Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00340	Plasma Cell Myeloma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00232	Kidney Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00602	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00496	Thyroid Gland Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00370	T-Lymphoblastic Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00463	T-Lymphoblastic Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00263	Ewing's Sarcoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM01242	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00581	Glioblastoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00002	Neuroblastoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00571	Pancreatic Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.G383C	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778

Showing 1 to 25 of 91 entries

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Drug responses associated with RALGPS1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ALTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	382:386	ALTSS	SPOP	0.8748	More...
Q6TFL3	Coiled-coil domain-containing protein 171	DEG_SPOP_SBC_1	1303:1307	ALTSS	SPOP	0.6534	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	37:41	ALTSS	SPOP	0.9991	More...
P40305	Interferon alpha-inducible protein 27, mitochondrial	DEG_SPOP_SBC_1	5:9	ALTSS	SPOP	0.8417	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	182:186	ALTSS	SPOP	0.8556	More...
Q5JS13	Ras-specific guanine nucleotide-releasing factor RalGPS1	DEG_SPOP_SBC_1	385:389	ALTSS	SPOP	0.7353	More...
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	288:292	ALTSS	SPOP	0.9872	More...
Q9NZ09	Ubiquitin-associated protein 1	DEG_SPOP_SBC_1	334:338	ALTSS	SPOP	0.9693	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	1299:1303	ALTSS	SPOP	0.9456	More...

Showing 1 to 9 of 9 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALTSS

Degron related mutations and impact score

Drug responses associated with RALGPS1 mutations

All proteins holding degron of ALTSS