DegronMD

Uniprot ID: O60343

Source protein: TBC1 domain family member 4

Source gene: TBC1D4

Class: DEG_SPOP_SBC_1

Location: 288:292

E3 ligase: SPOP

DEGRON score: 0.9872

ASA_SCORE: 68.74

COIL: 0.8072

CONS_SCORE: 0.2944

DSS_SCORE: 0.4268

HELIX: 0.1446

FCONS_SCORE: 0.9969

RIG_SCORE: 0.7031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G283A	TCGA-78-7220	LUAD	TCGA	ALTSS	DEG_SPOP_SBC_1	0.1944
p.G283A	DO24409	LUAD	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1944
p.R299Q	TCGA-AG-3902	READ	TCGA	ALTSS	DEG_SPOP_SBC_1	0.1389
p.R299Q	DO36407	READ	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.R299Q	SIDM01608	Endometrial Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.1389
p.R299Q	ACH-000990	Endometrial/Uterine Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.1389
p.G283W	TCGA-B5-A0JY	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	0.1944
p.E278K	DO3346	BRCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.0556
p.L285R	DO233129	GACA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.6944
p.T290N	DO229024	LICA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7055
p.I280M	DO231636	LINC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1111
p.E297K	DO222880	MELA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1944
p.A288S	DO27939	ORCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7588
p.M296I	DO43065	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.C298Y	DO43747	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.1667
p.G279C	SIDM00338	Acute Myeloid Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.0833
p.G279C	ACH-000439	Leukemia	CCLE	ALTSS	DEG_SPOP_SBC_1	0.0833
p.G279C	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.0833
p.R299W	ACH-001735	Leukemia	CCLE	ALTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	288:292	ALTSS	SPOP	0.9872	More...
P40305	Interferon alpha-inducible protein 27, mitochondrial	DEG_SPOP_SBC_1	5:9	ALTSS	SPOP	0.8417	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	37:41	ALTSS	SPOP	0.9991	More...
Q5JS13	Ras-specific guanine nucleotide-releasing factor RalGPS1	DEG_SPOP_SBC_1	385:389	ALTSS	SPOP	0.7353	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	1299:1303	ALTSS	SPOP	0.9456	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	182:186	ALTSS	SPOP	0.8556	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	382:386	ALTSS	SPOP	0.8748	More...
Q9NZ09	Ubiquitin-associated protein 1	DEG_SPOP_SBC_1	334:338	ALTSS	SPOP	0.9693	More...
Q6TFL3	Coiled-coil domain-containing protein 171	DEG_SPOP_SBC_1	1303:1307	ALTSS	SPOP	0.6534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons