DegronMD - Q96P56(CATSPER2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T384M	TCGA-A5-A0G2	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7423
p.T384M	TCGA-A5-A1OF	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7423
p.T384M	TCGA-D1-A103	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7423
p.T384M	DO42312	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7423
p.T384M	DO42568	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7423
p.T384M	DO41235	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7423
p.R395I	TCGA-B5-A1MR	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.0833
p.E458K	TCGA-BR-4184	STAD	TCGA	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.E458K	TCGA-DA-A95Y	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.S394L	TCGA-D3-A3MR	SKCM	TCGA	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.1111
p.E458V	TCGA-DA-A95Y	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.S448C	TCGA-SY-A9G5	BLCA	TCGA	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7541
p.E381K	TCGA-VS-A9UC	CESC	TCGA	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.3056
p.E381K	DO219732	CESC	ICGC	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.3056
p.S446C	DO51906	BLCA	ICGC	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7541
p.A382V	DO10858	ESAD	ICGC	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.5825
p.S459F	DO222749	MELA	ICGC	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation blocking phosphorylation signal	0.5278
p.T390M	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.2222
p.T390M	SIDM00657	Acute Myeloid Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.2222
p.T390M	SIDM01398	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.2222
p.T390M	SIDM01660	Kidney Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.2222
p.R380S	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.2778
p.S451F	SIDM00257	Neuroblastoma	GDSC	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.S451F	NB13	autonomic ganglia	COSMIC	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.S447C	ACH-000659	Lung Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.643
p.S385T	ACH-001061	Colon/Colorectal Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.6005
p.S447F	ACH-002280	Neuroblastoma	CCLE	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6871
p.S447F	NB13	autonomic ganglia	COSMIC	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6871
p.S445F	NB13	autonomic ganglia	COSMIC	VSSTS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056

Kaplan plot for CATSPER2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CATSPER2

UniProt ID: Q96P56

Entrez ID: 117155

Protein name: Cation channel sperm-associated protein 2 (CatSper2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CATSPER2 in