DegronMD - P42694(HELZ)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1604R	TCGA-06-5416	GBM	TCGA	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation rewiring degron network	0.1111
p.I1155T	TCGA-32-1977	GBM	TCGA	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.2778
p.I1155T	DO12076	GBM	ICGC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.2778
p.D1789Y	TCGA-37-5819	LUSC	TCGA	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation rewiring degron network	0.0833
p.D1789Y	DO26479	LUSC	ICGC	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation rewiring degron network	0.0833
p.S1795C	TCGA-49-4486	LUAD	TCGA	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.0556
p.S1764Y	TCGA-4Z-AA81	BLCA	TCGA	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation blocking phosphorylation signal	0.5
p.E1747K	TCGA-55-1596	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	1737:1741	Mutation rewiring degron network	0.1667
p.S1734C	TCGA-55-7574	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	1737:1741	Mutation rewiring degron network	0.25
p.Q1814E	TCGA-73-4662	LUAD	TCGA	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1944
p.Q1814E	DO24790	LUAD	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1944
p.P1801L	TCGA-AJ-A3OJ	UCEC	TCGA	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.2222
p.P1801L	DO42753	UCEC	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.2222
p.S1614R	TCGA-AN-A0XN	BRCA	TCGA	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation altering degron motif	0.8538
p.S1614R	DO3745	BRCA	ICGC	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation altering degron motif	0.8538
p.S1614R	DO229032	LICA	ICGC	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation altering degron motif	0.8538
p.P1817Q	TCGA-AO-A124	BRCA	TCGA	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1111
p.V1610I	TCGA-AX-A1C4	UCEC	TCGA	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation rewiring degron network	0.2778
p.P1102L	TCGA-AX-A2HD	UCEC	TCGA	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation rewiring degron network	0.3056
p.R1735Q	TCGA-B5-A0JY	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1737:1741	Mutation rewiring degron network	0.2778
p.R1735Q	DO43041	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1737:1741	Mutation rewiring degron network	0.2778
p.K1095N	TCGA-B5-A1MR	UCEC	TCGA	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation blocking ubiquitination signal	0.5556
p.R1160T	TCGA-C4-A0F6	BLCA	TCGA	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation altering degron motif	0.6765
p.T1120A	TCGA-CG-5721	STAD	TCGA	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation rewiring degron network	0.1667
p.R1751T	TCGA-CR-6484	HNSC	TCGA	VSSSS	DEG_SPOP_SBC_1	1737:1741	Mutation rewiring degron network	0.0556
p.L1168F	TCGA-CV-7568	HNSC	TCGA	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.2778
p.L1168V	TCGA-DK-A6B6	BLCA	TCGA	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.2778
p.L1168V	DO48576	BLCA	ICGC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.2778
p.P1817L	TCGA-DU-6392	LGG	TCGA	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1111
p.P1817L	TCGA-FS-A1ZK	SKCM	TCGA	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1111
p.P1817L	DO22237	LGG	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1111
p.P1817L	DO37474	SKCM	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1111
p.A1111V	TCGA-EB-A24D	SKCM	TCGA	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation altering degron motif	0.5825
p.A1111V	DO37440	SKCM	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation altering degron motif	0.5825
p.A1888V	TCGA-EY-A215	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.1944
p.P1812L	TCGA-FR-A726	SKCM	TCGA	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.25
p.P1812L	DO48665	SKCM	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.25
p.P1151H	TCGA-FS-A1ZN	SKCM	TCGA	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.1667
p.P1151H	DO38165	SKCM	ICGC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.1667
p.A1876V	TCGA-G4-6304	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.25
p.A1876V	DO10639	COAD	ICGC	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.25
p.P1151S	TCGA-GN-A26C	SKCM	TCGA	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.1667
p.F1798C	TCGA-IB-7651	PAAD	TCGA	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1389
p.F1798C	DO46657	PAAD	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1389
p.N1635I	TCGA-QB-A6FS	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation rewiring degron network	0.0556
p.N1635I	DO218896	SKCA	ICGC	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation rewiring degron network	0.0556
p.N1635I	DO48654	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation rewiring degron network	0.0556
p.S1765Y	DO51868	BLCA	ICGC	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation blocking phosphorylation signal	0.5278
p.R1161T	DO508	BLCA	ICGC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation altering degron motif	0.7876
p.P1818Q	DO1287	BRCA	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.0833
p.E1774D	DO234230	ESAD	ICGC	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation altering degron motif	0.6758
p.L1869I	DO233865	GACA	ICGC	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0556
p.A1104T	DO233941	GACA	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation altering degron motif	0.7139
p.L1605R	DO10880	GBM	ICGC	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation rewiring degron network	0.1389
p.L1169F	DO14160	HNSC	ICGC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.25
p.S1120R	DO229346	LAML	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation rewiring degron network	0.1667
p.N1634Y	DO228313	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation rewiring degron network	0.0833
p.H1172Q	DO228971	LICA	ICGC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.1667
p.Q1124K	DO228985	LICA	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation rewiring degron network	0.0556
p.Q1148K	DO228985	LICA	ICGC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.0833
p.H1627N	DO228986	LICA	ICGC	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation rewiring degron network	0.1667
p.H1627N	DO228986	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation rewiring degron network	0.2778
p.P1750T	DO229018	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1737:1741	Mutation rewiring degron network	0.0833
p.H1116N	DO229029	LICA	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation rewiring degron network	0.2778
p.H1116N	DO229026	LICA	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation rewiring degron network	0.2778
p.P1173T	DO229024	LICA	ICGC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.1389
p.H1628Q	DO229027	LICA	ICGC	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation rewiring degron network	0.1389
p.H1628Q	DO229027	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation rewiring degron network	0.25
p.Q1815K	DO229032	LICA	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1667
p.A1617E	DO229038	LICA	ICGC	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation altering degron motif	0.659
p.P1165Q	DO229009	LICA	ICGC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation altering degron motif	0.5924
p.A1877T	DO50760	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.2778
p.L1113V	DO23462	LINC	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation altering degron motif	0.6765
p.R1110G	DO45049	LINC	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation altering degron motif	0.6457
p.E1803K	DO45299	LIRI	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.2778
p.E1748K	DO25481	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1737:1741	Mutation rewiring degron network	0.1389
p.S1796C	DO23786	LUAD	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.0833
p.S1735C	DO23986	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1737:1741	Mutation rewiring degron network	0.2778
p.P1622H	DO220901	MELA	ICGC	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation altering degron motif	0.6583
p.P1152S	DO37782	SKCM	ICGC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.1944
p.T1121A	DO38192	STAD	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation rewiring degron network	0.1389
p.I1816F	DO231315	THCA	ICGC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1389
p.K1096N	DO41758	UCEC	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation blocking ubiquitination signal	0.5833
p.P1103L	DO42608	UCEC	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	1103:1114	Mutation altering degron motif	0.7582
p.V1611I	DO42480	UCEC	ICGC	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation rewiring degron network	0.3056
p.V1611I	DO42480	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation rewiring degron network	0.0556
p.A1889V	DO42665	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.1667
p.P1893L	SIDM00399	Head and Neck Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0556
p.P1893L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0556
p.P1893L	KYSE-220	oesophagus	COSMIC	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0556
p.P1893L	SCC90	upper aerodigestive tract	COSMIC	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0556
p.S1772F	SIDM00967	Ovarian Carcinoma	GDSC	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation rewiring degron network	0.2778
p.S1772F	OVCA420	ovary	COSMIC	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation rewiring degron network	0.2778
p.C1785R	SIDM00087	Plasma Cell Myeloma	GDSC	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation substituting flanking lysine	0.3056
p.C1785R	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation substituting flanking lysine	0.3056
p.S1624F	SIDM00007	Other Solid Cancers	GDSC	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation altering degron motif	0.7982
p.S1624F	MCC13	skin	COSMIC	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation altering degron motif	0.7982
p.H1172Y	SIDM00539	Esophageal Carcinoma	GDSC	NPIRAYTPPP	CBL_PTK	1157:1166	Mutation rewiring degron network	0.1667
p.Y1814H	SIDM00379	Glioma	GDSC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1944
p.Y1814H	SK-MG-1	central nervous system	COSMIC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1944
p.F1797I	SIDM01612	Endometrial Carcinoma	GDSC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.1111
p.C1784R	ACH-000817	Myeloma	CCLE	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation rewiring degron network	0.2222
p.C1784R	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation rewiring degron network	0.2222
p.A1876T	ACH-000941	Endometrial/Uterine Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.25
p.F1796I	ACH-000946	Endometrial/Uterine Cancer	CCLE	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.0833
p.A1617T	ACH-000954	Endometrial/Uterine Cancer	CCLE	SRSPPAVPSP	DEG_COP1_1	1612:1621	Mutation altering degron motif	0.6028
p.S1881N	ACH-000960	Leukemia	CCLE	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation altering degron motif	0.7069
p.S1809P	ACH-001028	Rhabdoid	CCLE	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation altering degron motif	0.6752
p.P1892L	ACH-001228		CCLE	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0833
p.P1892L	ACH-002263	Esophageal Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0833
p.P1892L	SCC90	upper aerodigestive tract	COSMIC	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0833
p.P1892L	KYSE-220	oesophagus	COSMIC	ANSSS	DEG_SPOP_SBC_1	1879:1883	Mutation rewiring degron network	0.0833
p.S1623F	ACH-001550	Skin Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation altering degron motif	0.7982
p.S1623F	MCC13	skin	COSMIC	PPSST	DEG_SPOP_SBC_1	1621:1625	Mutation altering degron motif	0.7982
p.V1805I	ACH-002005	Skin Cancer	CCLE	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation altering degron motif	0.7076
p.S1771F	ACH-002181	Ovarian Cancer	CCLE	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation rewiring degron network	0.25
p.S1771F	OVCA420	ovary	COSMIC	VSTPQDS	DEG_SCF_FBW7_1	1774:1780	Mutation rewiring degron network	0.25
p.Y1813H	ACH-002304	Brain Cancer	CCLE	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation blocking phosphorylation signal	0.6667
p.Y1813H	SK-MG-1	central nervous system	COSMIC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation blocking phosphorylation signal	0.6667
p.P1812S	ACH-002396	Bone Cancer	CCLE	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.25
p.P1812S	Sarc9371	bone	COSMIC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation rewiring degron network	0.25
p.P1813S	Sarc9371	bone	COSMIC	VNTTS	DEG_SPOP_SBC_1	1805:1809	Mutation blocking phosphorylation signal	0.6667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HELZ

UniProt ID: P42694

Entrez ID: 9931

Protein name: Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HELZ in