DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VNTTS
Uniprot ID:
P42694
Source protein:
Probable helicase with zinc finger domain
Source gene:
HELZ
Class:
DEG_SPOP_SBC_1
Location:
1805:1809
E3 ligase:
SPOP
DEGRON score:
0.9851
ASA_SCORE:
76.42
COIL:
0.8698
CONS_SCORE:
0.3443
DSS_SCORE:
0.5135
HELIX:
0.0422
FCONS_SCORE:
0.7862
RIG_SCORE:
0.6731
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1795C
TCGA-49-4486
LUAD
TCGA
VNTTS
DEG_SPOP_SBC_1
0.0556
p.Q1814E
TCGA-73-4662
LUAD
TCGA
VNTTS
DEG_SPOP_SBC_1
0.1944
p.Q1814E
DO24790
LUAD
ICGC
VNTTS
DEG_SPOP_SBC_1
0.1944
p.P1801L
TCGA-AJ-A3OJ
UCEC
TCGA
VNTTS
DEG_SPOP_SBC_1
0.2222
p.P1801L
DO42753
UCEC
ICGC
VNTTS
DEG_SPOP_SBC_1
0.2222
p.P1817Q
TCGA-AO-A124
BRCA
TCGA
VNTTS
DEG_SPOP_SBC_1
0.1111
p.P1817L
TCGA-DU-6392
LGG
TCGA
VNTTS
DEG_SPOP_SBC_1
0.1111
p.P1817L
TCGA-FS-A1ZK
SKCM
TCGA
VNTTS
DEG_SPOP_SBC_1
0.1111
p.P1817L
DO22237
LGG
ICGC
VNTTS
DEG_SPOP_SBC_1
0.1111
p.P1817L
DO37474
SKCM
ICGC
VNTTS
DEG_SPOP_SBC_1
0.1111
p.P1812L
TCGA-FR-A726
SKCM
TCGA
VNTTS
DEG_SPOP_SBC_1
0.25
p.P1812L
DO48665
SKCM
ICGC
VNTTS
DEG_SPOP_SBC_1
0.25
p.F1798C
TCGA-IB-7651
PAAD
TCGA
VNTTS
DEG_SPOP_SBC_1
0.1389
p.F1798C
DO46657
PAAD
ICGC
VNTTS
DEG_SPOP_SBC_1
0.1389
p.P1818Q
DO1287
BRCA
ICGC
VNTTS
DEG_SPOP_SBC_1
0.0833
p.Q1815K
DO229032
LICA
ICGC
VNTTS
DEG_SPOP_SBC_1
0.1667
p.E1803K
DO45299
LIRI
ICGC
VNTTS
DEG_SPOP_SBC_1
0.2778
p.S1796C
DO23786
LUAD
ICGC
VNTTS
DEG_SPOP_SBC_1
0.0833
p.I1816F
DO231315
THCA
ICGC
VNTTS
DEG_SPOP_SBC_1
0.1389
p.Y1814H
SIDM00379
Glioma
GDSC
VNTTS
DEG_SPOP_SBC_1
0.1944
p.Y1814H
SK-MG-1
central_nervous_system
COSMIC
VNTTS
DEG_SPOP_SBC_1
0.1944
p.F1797I
SIDM01612
Endometrial Carcinoma
GDSC
VNTTS
DEG_SPOP_SBC_1
0.1111
p.F1796I
ACH-000946
Endometrial/Uterine Cancer
CCLE
VNTTS
DEG_SPOP_SBC_1
0.0833
p.S1809P
ACH-001028
Rhabdoid
CCLE
VNTTS
DEG_SPOP_SBC_1
0.6752
p.V1805I
ACH-002005
Skin Cancer
CCLE
VNTTS
DEG_SPOP_SBC_1
0.7076
p.Y1813H
ACH-002304
Brain Cancer
CCLE
VNTTS
DEG_SPOP_SBC_1
0.6667
p.Y1813H
SK-MG-1
central_nervous_system
COSMIC
VNTTS
DEG_SPOP_SBC_1
0.6667
p.P1812S
ACH-002396
Bone Cancer
CCLE
VNTTS
DEG_SPOP_SBC_1
0.25
p.P1812S
Sarc9371
bone
COSMIC
VNTTS
DEG_SPOP_SBC_1
0.25
p.P1813S
Sarc9371
bone
COSMIC
VNTTS
DEG_SPOP_SBC_1
0.6667
Drug responses associated with HELZ mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VNTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P42694
Probable helicase with zinc finger domain
DEG_SPOP_SBC_1
1805:1809
VNTTS
SPOP
0.9851
More...
Q8IZP9
Adhesion G-protein coupled receptor G2
DEG_SPOP_SBC_1
356:360
VNTTS
SPOP
0.5205
More...