DegronMD

Uniprot ID: Q8IZP9

Source protein: Adhesion G-protein coupled receptor G2

Source gene: ADGRG2

Class: DEG_SPOP_SBC_1

Location: 356:360

E3 ligase: SPOP

DEGRON score: 0.5205

ASA_SCORE: 80.8

COIL: 0.6288

CONS_SCORE: 0.3638

DSS_SCORE: 0.528

HELIX: 0.0688

FCONS_SCORE: 0.9211

RIG_SCORE: 0.6658

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V350M	SIDM01295	Pancreatic Carcinoma	GDSC	VNTTS	DEG_SPOP_SBC_1	0.1667
p.P348L	SIDM00458	Acute Myeloid Leukemia	GDSC	VNTTS	DEG_SPOP_SBC_1	0.1111
p.P348L	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	VNTTS	DEG_SPOP_SBC_1	0.1111
p.P348T	SIDM00458	Acute Myeloid Leukemia	GDSC	VNTTS	DEG_SPOP_SBC_1	0.1111
p.P348T	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	VNTTS	DEG_SPOP_SBC_1	0.1111
p.A361T	SIDM00596	Endometrial Carcinoma	GDSC	VNTTS	DEG_SPOP_SBC_1	0.3056
p.A361T	HEC-1	endometrium	COSMIC	VNTTS	DEG_SPOP_SBC_1	0.3056
p.V356F	SIDM00560	Gastric Carcinoma	GDSC	VNTTS	DEG_SPOP_SBC_1	0.7068
p.V356F	MKN7	stomach	COSMIC	VNTTS	DEG_SPOP_SBC_1	0.7068
p.A358T	HEC-1	endometrium	COSMIC	VNTTS	DEG_SPOP_SBC_1	0.7139
p.A347T	HEC-1	endometrium	COSMIC	VNTTS	DEG_SPOP_SBC_1	0.0833
p.V353F	MKN7	stomach	COSMIC	VNTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1805:1809	VNTTS	SPOP	0.9851	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	356:360	VNTTS	SPOP	0.5205	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons