DegronMD

Uniprot ID: P42694

Source protein: Probable helicase with zinc finger domain

Source gene: HELZ

Class: DEG_SCF_FBW7_1

Location: 1774:1780

E3 ligase: FBXW7

DEGRON score: 0.9314

ASA_SCORE: 70

COIL: 0.7829

CONS_SCORE: 0.3723

DSS_SCORE: 0.537

HELIX: 0.1854

FCONS_SCORE: 0.92

RIG_SCORE: 0.6803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1789Y	TCGA-37-5819	LUSC	TCGA	VSTPQDS	DEG_SCF_FBW7_1	0.0833
p.D1789Y	DO26479	LUSC	ICGC	VSTPQDS	DEG_SCF_FBW7_1	0.0833
p.S1764Y	TCGA-4Z-AA81	BLCA	TCGA	VSTPQDS	DEG_SCF_FBW7_1	0.5
p.S1765Y	DO51868	BLCA	ICGC	VSTPQDS	DEG_SCF_FBW7_1	0.5278
p.E1774D	DO234230	ESAD	ICGC	VSTPQDS	DEG_SCF_FBW7_1	0.6758
p.S1772F	SIDM00967	Ovarian Carcinoma	GDSC	VSTPQDS	DEG_SCF_FBW7_1	0.2778
p.S1772F	OVCA420	ovary	COSMIC	VSTPQDS	DEG_SCF_FBW7_1	0.2778
p.C1785R	SIDM00087	Plasma Cell Myeloma	GDSC	VSTPQDS	DEG_SCF_FBW7_1	0.3056
p.C1785R	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VSTPQDS	DEG_SCF_FBW7_1	0.3056
p.C1784R	ACH-000817	Myeloma	CCLE	VSTPQDS	DEG_SCF_FBW7_1	0.2222
p.C1784R	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VSTPQDS	DEG_SCF_FBW7_1	0.2222
p.S1771F	ACH-002181	Ovarian Cancer	CCLE	VSTPQDS	DEG_SCF_FBW7_1	0.25
p.S1771F	OVCA420	ovary	COSMIC	VSTPQDS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42694	Probable helicase with zinc finger domain	DEG_SCF_FBW7_1	1774:1780	VSTPQDS	FBXW7	0.9314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons