DegronMD

Uniprot ID: P42694

Source protein: Probable helicase with zinc finger domain

Source gene: HELZ

Class: DEG_SPOP_SBC_1

Location: 1879:1883

E3 ligase: SPOP

DEGRON score: 0.986

ASA_SCORE: 76.86

COIL: 0.9408

CONS_SCORE: 0.3734

DSS_SCORE: 0.6802

HELIX: 0.046

FCONS_SCORE: 0.8497

RIG_SCORE: 0.5516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1888V	TCGA-EY-A215	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1944
p.A1876V	TCGA-G4-6304	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.25
p.A1876V	DO10639	COAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.25
p.L1869I	DO233865	GACA	ICGC	ANSSS	DEG_SPOP_SBC_1	0.0556
p.A1877T	DO50760	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	0.2778
p.A1889V	DO42665	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1667
p.P1893L	SIDM00399	Head and Neck Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.0556
p.P1893L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.0556
p.P1893L	KYSE-220	oesophagus	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.0556
p.P1893L	SCC90	upper_aerodigestive_tract	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.0556
p.A1876T	ACH-000941	Endometrial/Uterine Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	0.25
p.S1881N	ACH-000960	Leukemia	CCLE	ANSSS	DEG_SPOP_SBC_1	0.7069
p.P1892L	ACH-001228		CCLE	ANSSS	DEG_SPOP_SBC_1	0.0833
p.P1892L	ACH-002263	Esophageal Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	0.0833
p.P1892L	SCC90	upper_aerodigestive_tract	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.0833
p.P1892L	KYSE-220	oesophagus	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	213:217	ANSSS	SPOP	0.9966	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1879:1883	ANSSS	SPOP	0.986	More...
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SPOP_SBC_1	1021:1025	ANSSS	SPOP	0.9968	More...
Q06945	Transcription factor SOX-4	DEG_SPOP_SBC_1	139:143	ANSSS	SPOP	0.9719	More...
Q6UWB1	Interleukin-27 receptor subunit alpha	DEG_SPOP_SBC_1	562:566	ANSSS	SPOP	0.7903	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	551:555	ANSSS	SPOP	0.983	More...
Q8IZW8	Tensin-4	DEG_SPOP_SBC_1	311:315	ANSSS	SPOP	0.8185	More...
Q99743	Neuronal PAS domain-containing protein 2	DEG_SPOP_SBC_1	720:724	ANSSS	SPOP	0.9105	More...
Q9BRS8	La-related protein 6	DEG_SPOP_SBC_1	336:340	ANSSS	SPOP	0.9686	More...
Q9HCD5	Nuclear receptor coactivator 5	DEG_SPOP_SBC_1	446:450	ANSSS	SPOP	0.8794	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_SPOP_SBC_1	729:733	ANSSS	SPOP	0.8431	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	73:77	ANSSS	SPOP	0.9841	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_SPOP_SBC_1	775:779	ANSSS	SPOP	0.9091	More...
Q9H1C0	Lysophosphatidic acid receptor 5	DEG_SPOP_SBC_1	3:7	ANSSS	SPOP	0.6526	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	429:433	ANSSS	SPOP	0.756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons