DegronMD - Q6ZNA4(RNF111)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S32N	TCGA-06-5416	GBM	TCGA	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.2222
p.S32N	DO10880	GBM	ICGC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.2222
p.E41Q	TCGA-22-5473	LUSC	TCGA	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.6744
p.E41Q	DO26467	LUSC	ICGC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.6744
p.I43T	TCGA-32-2634	GBM	TCGA	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.2778
p.I43T	DO13995	GBM	ICGC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.2778
p.S419C	TCGA-4P-AA8J	HNSC	TCGA	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.0833
p.S419C	DO52027	HNSC	ICGC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.0833
p.V387I	TCGA-85-8288	LUSC	TCGA	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1111
p.V387I	DO26963	LUSC	ICGC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1111
p.V387I	SIDM02049	Pancreatic Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1111
p.A409T	TCGA-A5-A0G2	UCEC	TCGA	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0556
p.A409T	TCGA-AJ-A3EL	UCEC	TCGA	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0556
p.A409T	TCGA-VQ-A8P2	STAD	TCGA	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0556
p.A409T	DO51761	STAD	ICGC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0556
p.A409T	DO41542	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0556
p.A409T	DO41235	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0556
p.R244Q	TCGA-A5-A2K5	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1389
p.R244Q	DO41379	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1389
p.R598Q	TCGA-AA-3815	COAD	TCGA	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.3056
p.R598Q	TCGA-AN-A046	BRCA	TCGA	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.3056
p.R598Q	DO1285	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.3056
p.R598Q	DO9924	COAD	ICGC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.3056
p.R598Q	DO50331	ESAD	ICGC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.3056
p.A600T	TCGA-AP-A1DV	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.25
p.A600T	DO43186	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.25
p.R245I	TCGA-AP-A1E0	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1667
p.R245I	DO43154	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1667
p.G556D	TCGA-AX-A0J1	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.3056
p.G556D	DO41199	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.3056
p.Y559C	TCGA-BB-A6UO	HNSC	TCGA	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.2222
p.Y559C	DO218985	HNSC	ICGC	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.2222
p.T654A	TCGA-BR-4280	STAD	TCGA	PPPY	ITCH	647:650	Mutation rewiring degron network	0.2222
p.T654A	DO38663	STAD	ICGC	PPPY	ITCH	647:650	Mutation rewiring degron network	0.2222
p.I601V	TCGA-BR-6566	STAD	TCGA	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2222
p.I601V	DO38217	STAD	ICGC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2222
p.S404L	TCGA-CA-6717	COAD	TCGA	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1944
p.S404L	DO8264	COAD	ICGC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1944
p.D260Y	TCGA-D1-A16X	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1944
p.D260Y	DO41799	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1944
p.P40Q	TCGA-D3-A2JP	SKCM	TCGA	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.5924
p.P40Q	DO47407	SKCM	ICGC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.5924
p.A409P	TCGA-DD-AACI	LIHC	TCGA	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0556
p.A409P	DO52205	LIHC	ICGC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0556
p.E258K	TCGA-DR-A0ZM	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.25
p.E258K	DO6254	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.25
p.I43N	TCGA-E9-A243	BRCA	TCGA	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.2778
p.I43N	DO4803	BRCA	ICGC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.2778
p.G35E	TCGA-EE-A2GJ	SKCM	TCGA	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.3056
p.G35E	DO37746	SKCM	ICGC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.3056
p.N552T	TCGA-EI-6917	READ	TCGA	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation altering degron motif	0.5944
p.N552T	DO36881	READ	ICGC	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation altering degron motif	0.5944
p.H659Y	TCGA-FD-A62P	BLCA	TCGA	PPPY	ITCH	647:650	Mutation rewiring degron network	0.0833
p.H659Y	DO44054	BLCA	ICGC	PPPY	ITCH	647:650	Mutation rewiring degron network	0.0833
p.S423F	TCGA-G2-A2EF	BLCA	TCGA	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1944
p.S423F	TCGA-XF-A8HE	BLCA	TCGA	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1944
p.S423F	DO49797	BLCA	ICGC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1944
p.S423F	DO726	BLCA	ICGC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1944
p.S441L	TCGA-G2-A2EF	BLCA	TCGA	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.0833
p.S441L	DO726	BLCA	ICGC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.0833
p.S253C	TCGA-G2-A3VY	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation altering degron motif	0.7541
p.S253C	DO590	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation altering degron motif	0.7541
p.D388N	TCGA-K4-A6MB	BLCA	TCGA	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1389
p.D388N	DO44077	BLCA	ICGC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1389
p.V594F	TCGA-KL-8343	KICH	TCGA	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.5957
p.V594F	DO220351	KICH	ICGC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.5957
p.H659R	TCGA-LN-A9FO	ESCA	TCGA	PPPY	ITCH	647:650	Mutation rewiring degron network	0.0833
p.E439K	TCGA-T3-A92N	HNSC	TCGA	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1389
p.E439K	DO219073	HNSC	ICGC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.1389
p.D136A	TCGA-VQ-A8P2	STAD	TCGA	LGTPSDE	DEG_SCF_FBW7_2	122:128	Mutation rewiring degron network	0.1111
p.D136A	DO51761	STAD	ICGC	LGTPSDE	DEG_SCF_FBW7_2	122:128	Mutation rewiring degron network	0.1111
p.P656R	TCGA-XF-A9SZ	BLCA	TCGA	PPPY	ITCH	647:650	Mutation rewiring degron network	0.1667
p.P656R	DO51919	BLCA	ICGC	PPPY	ITCH	647:650	Mutation rewiring degron network	0.1667
p.C592Y	TCGA-XF-A9T8	BLCA	TCGA	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.3056
p.C592Y	DO51927	BLCA	ICGC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.3056
p.V395A	DO8858	COAD	ICGC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.5825
p.L653F	DO228815	LICA	ICGC	PPPY	ITCH	647:650	Mutation rewiring degron network	0.25
p.L653F	DO230937	LUSC	ICGC	PPPY	ITCH	647:650	Mutation rewiring degron network	0.25
p.L653F	DO224619	LUSC	ICGC	PPPY	ITCH	647:650	Mutation rewiring degron network	0.25
p.S135I	DO228939	LICA	ICGC	LGTPSDE	DEG_SCF_FBW7_2	122:128	Mutation rewiring degron network	0.1389
p.H560L	DO232028	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1944
p.S432I	DO229029	LICA	ICGC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation altering degron motif	0.7341
p.A607S	DO229024	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.0556
p.A587S	DO229041	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1667
p.A45S	DO229009	LICA	ICGC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation rewiring degron network	0.2222
p.N112D	DO231760	LINC	ICGC	LGTPSDE	DEG_SCF_FBW7_2	122:128	Mutation rewiring degron network	0.0556
p.S596F	DO222662	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.7982
p.S419P	DO35122	PACA	ICGC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.0833
p.P396T	DO52124	PAEN	ICGC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.5919
p.H560Y	DO229470	SKCA	ICGC	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1944
p.T418A	SIDM02059	Colorectal Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.0556
p.G584A	SIDM01956	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.0833
p.E403D	SIDM00845	Burkitt's Lymphoma	GDSC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.2222
p.A406T	SIDM00845	Burkitt's Lymphoma	GDSC	VPTTS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1389
p.K47R	SIDM00266	Ewing's Sarcoma	GDSC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation blocking ubiquitination signal	0.6111
p.K47R	ES1	bone	COSMIC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation blocking ubiquitination signal	0.6111
p.S554C	SIDM00333	Endometrial Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation altering degron motif	0.7541
p.S554C	ACH-000988	Endometrial/Uterine Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation altering degron motif	0.7541
p.S554C	MFE-319	endometrium	COSMIC	ANSSS	DEG_SPOP_SBC_1	551:555	Mutation altering degron motif	0.7541
p.S435T	SIDM00681	Colorectal Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.S435T	SIDM00183	Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.S435T	SIDM01641	Non-Cancerous	GDSC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.S435T	SIDM00929	Chondrosarcoma	GDSC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.S435T	SIDM01648	Non-Cancerous	GDSC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.S435T	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.S435T	SIDM01640	Acute Myeloid Leukemia	GDSC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.I36F	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.6304
p.I36F	TE-9	oesophagus	COSMIC	ILLHPE	LIG_APCC_ABBA_1	36:41	Mutation altering degron motif	0.6304
p.A428P	SIDM01577	Plasma Cell Myeloma	GDSC	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation altering degron motif	0.6392
p.A428P	ACH-000889	Myeloma	CCLE	AVTSS	DEG_SPOP_SBC_1	428:432	Mutation altering degron motif	0.6392
p.K246N	SIDM01725	Non-Cancerous	GDSC	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation substituting flanking lysine	0.3056
p.K246N	ACH-000284	Non-Cancerous	CCLE	PSSSS	DEG_SPOP_SBC_1	251:255	Mutation substituting flanking lysine	0.3056
p.P593L	ACH-002089	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.7582
p.P593L	201T	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF111

UniProt ID: Q6ZNA4

Entrez ID: 54778

Protein name: E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF111 in