DegronMD

Uniprot ID: Q6ZNA4

Source protein: E3 ubiquitin-protein ligase Arkadia

Source gene: RNF111

Class: DEG_SCF_FBW7_2

Location: 122:128

E3 ligase: FBXW7

DEGRON score: 0.9893

ASA_SCORE: 99

COIL: 0.9537

CONS_SCORE: 0.4492

DSS_SCORE: 0.592

HELIX: 0.0276

FCONS_SCORE: 1.0498

RIG_SCORE: 0.6427

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D136A	TCGA-VQ-A8P2	STAD	TCGA	LGTPSDE	DEG_SCF_FBW7_2	0.1111
p.D136A	DO51761	STAD	ICGC	LGTPSDE	DEG_SCF_FBW7_2	0.1111
p.S135I	DO228939	LICA	ICGC	LGTPSDE	DEG_SCF_FBW7_2	0.1389
p.N112D	DO231760	LINC	ICGC	LGTPSDE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SCF_FBW7_2	122:128	LGTPSDE	FBXW7	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons