DegronMD

Uniprot ID: Q6ZNA4

Source protein: E3 ubiquitin-protein ligase Arkadia

Source gene: RNF111

Class: LIG_APCC_ABBA_1

Location: 36:41

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.959

ASA_SCORE: 69.3

COIL: 0.7323

CONS_SCORE: 0.4323

DSS_SCORE: 0.4406

HELIX: 0.1558

FCONS_SCORE: 1.019

RIG_SCORE: 0.7576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S32N	TCGA-06-5416	GBM	TCGA	ILLHPE	LIG_APCC_ABBA_1	0.2222
p.S32N	DO10880	GBM	ICGC	ILLHPE	LIG_APCC_ABBA_1	0.2222
p.E41Q	TCGA-22-5473	LUSC	TCGA	ILLHPE	LIG_APCC_ABBA_1	0.6744
p.E41Q	DO26467	LUSC	ICGC	ILLHPE	LIG_APCC_ABBA_1	0.6744
p.I43T	TCGA-32-2634	GBM	TCGA	ILLHPE	LIG_APCC_ABBA_1	0.2778
p.I43T	DO13995	GBM	ICGC	ILLHPE	LIG_APCC_ABBA_1	0.2778
p.P40Q	TCGA-D3-A2JP	SKCM	TCGA	ILLHPE	LIG_APCC_ABBA_1	0.5924
p.P40Q	DO47407	SKCM	ICGC	ILLHPE	LIG_APCC_ABBA_1	0.5924
p.I43N	TCGA-E9-A243	BRCA	TCGA	ILLHPE	LIG_APCC_ABBA_1	0.2778
p.I43N	DO4803	BRCA	ICGC	ILLHPE	LIG_APCC_ABBA_1	0.2778
p.G35E	TCGA-EE-A2GJ	SKCM	TCGA	ILLHPE	LIG_APCC_ABBA_1	0.3056
p.G35E	DO37746	SKCM	ICGC	ILLHPE	LIG_APCC_ABBA_1	0.3056
p.A45S	DO229009	LICA	ICGC	ILLHPE	LIG_APCC_ABBA_1	0.2222
p.K47R	SIDM00266	Ewing's Sarcoma	GDSC	ILLHPE	LIG_APCC_ABBA_1	0.6111
p.K47R	ES1	bone	COSMIC	ILLHPE	LIG_APCC_ABBA_1	0.6111
p.I36F	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ILLHPE	LIG_APCC_ABBA_1	0.6304
p.I36F	TE-9	oesophagus	COSMIC	ILLHPE	LIG_APCC_ABBA_1	0.6304

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	LIG_APCC_ABBA_1	36:41	ILLHPE	APC,CDC20,FZR1	0.959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons