DegronMD - Q9BRS8(LARP6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S421Y	TCGA-06-1802	GBM	TCGA	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation blocking phosphorylation signal	0.6667
p.S421Y	DO12100	GBM	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation blocking phosphorylation signal	0.6667
p.R437H	TCGA-A5-A1OF	UCEC	TCGA	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1389
p.R437H	TCGA-J2-8192	LUAD	TCGA	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1389
p.R437H	DO23806	LUAD	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1389
p.R437H	DO42568	UCEC	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1389
p.Q328H	TCGA-A5-A1OF	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.Q328H	DO42568	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.M417V	TCGA-AA-3492	COAD	TCGA	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1111
p.M417V	DO8224	COAD	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1111
p.R436H	TCGA-AA-A01R	COAD	TCGA	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1667
p.R436H	DO7934	COAD	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1667
p.R436C	TCGA-B5-A3FC	UCEC	TCGA	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1667
p.R436C	DO230335	COCA	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1667
p.R436C	DO41871	UCEC	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1667
p.R436C	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1667
p.R436C	ACH-002307	Lymphoma	CCLE	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1667
p.R436C	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1667
p.V425I	TCGA-C5-A7UI	CESC	TCGA	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation altering degron motif	0.5965
p.V425I	DO49892	CESC	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation altering degron motif	0.5965
p.R435W	TCGA-CV-7178	HNSC	TCGA	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1944
p.R435W	DO14774	HNSC	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1944
p.P342L	TCGA-DD-AADN	LIHC	TCGA	ANSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2778
p.P342L	DO52239	LIHC	ICGC	ANSSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2778
p.I291T	TCGA-DX-AB2Q	SARC	TCGA	GKENM	DEG_APCC_KENBOX_2	282:286	Mutation rewiring degron network	0.1944
p.I291T	DO220087	SARC	ICGC	GKENM	DEG_APCC_KENBOX_2	282:286	Mutation rewiring degron network	0.1944
p.G429R	TCGA-EO-A3AS	UCEC	TCGA	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation altering degron motif	0.6457
p.G429R	DO43466	UCEC	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation altering degron motif	0.6457
p.G429S	DO48395	BLCA	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation altering degron motif	0.5882
p.E440K	DO234270	ESAD	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.0556
p.P427L	DO11854	GBM	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation altering degron motif	0.7582
p.P427T	DO229022	LICA	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation altering degron motif	0.7031
p.P431T	DO229035	LICA	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.3056
p.T278K	DO229037	LICA	ICGC	GKENM	DEG_APCC_KENBOX_2	282:286	Mutation rewiring degron network	0.2222
p.R434W	DO228496	MALY	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.2222
p.R437C	DO48904	PBCA	ICGC	VTPSGS	DEG_SCF_FBW7_1	425:430	Mutation rewiring degron network	0.1389
p.K283E	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	GKENM	DEG_APCC_KENBOX_2	282:286	Mutation altering degron motif	0.7022
p.K283E	ACH-000837	Lung Cancer	CCLE	GKENM	DEG_APCC_KENBOX_2	282:286	Mutation altering degron motif	0.7022
p.K283E	NCI-H322M	lung	COSMIC	GKENM	DEG_APCC_KENBOX_2	282:286	Mutation altering degron motif	0.7022
p.H273Y	ACH-002202	Gastric Cancer	CCLE	GKENM	DEG_APCC_KENBOX_2	282:286	Mutation rewiring degron network	0.0833
p.H273Y	TMK-1	stomach	COSMIC	GKENM	DEG_APCC_KENBOX_2	282:286	Mutation rewiring degron network	0.0833

Kaplan plot for LARP6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LARP6

UniProt ID: Q9BRS8

Entrez ID: 55323

Protein name: La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LARP6 in