DegronMD

Uniprot ID: Q9BRS8

Source protein: La-related protein 6

Source gene: LARP6

Class: DEG_SCF_FBW7_1

Location: 425:430

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 59.5333

COIL: 0.9268

CONS_SCORE: 0.491

DSS_SCORE: 0.5596

HELIX: 0.0577

FCONS_SCORE: 1.0336

RIG_SCORE: 0.6103

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S421Y	TCGA-06-1802	GBM	TCGA	VTPSGS	DEG_SCF_FBW7_1	0.6667
p.S421Y	DO12100	GBM	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.6667
p.R437H	TCGA-A5-A1OF	UCEC	TCGA	VTPSGS	DEG_SCF_FBW7_1	0.1389
p.R437H	TCGA-J2-8192	LUAD	TCGA	VTPSGS	DEG_SCF_FBW7_1	0.1389
p.R437H	DO23806	LUAD	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.1389
p.R437H	DO42568	UCEC	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.1389
p.M417V	TCGA-AA-3492	COAD	TCGA	VTPSGS	DEG_SCF_FBW7_1	0.1111
p.M417V	DO8224	COAD	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.1111
p.R436H	TCGA-AA-A01R	COAD	TCGA	VTPSGS	DEG_SCF_FBW7_1	0.1667
p.R436H	DO7934	COAD	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.1667
p.R436C	TCGA-B5-A3FC	UCEC	TCGA	VTPSGS	DEG_SCF_FBW7_1	0.1667
p.R436C	DO230335	COCA	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.1667
p.R436C	DO41871	UCEC	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.1667
p.R436C	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPSGS	DEG_SCF_FBW7_1	0.1667
p.R436C	ACH-002307	Lymphoma	CCLE	VTPSGS	DEG_SCF_FBW7_1	0.1667
p.R436C	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSGS	DEG_SCF_FBW7_1	0.1667
p.V425I	TCGA-C5-A7UI	CESC	TCGA	VTPSGS	DEG_SCF_FBW7_1	0.5965
p.V425I	DO49892	CESC	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.5965
p.R435W	TCGA-CV-7178	HNSC	TCGA	VTPSGS	DEG_SCF_FBW7_1	0.1944
p.R435W	DO14774	HNSC	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.1944
p.G429R	TCGA-EO-A3AS	UCEC	TCGA	VTPSGS	DEG_SCF_FBW7_1	0.6457
p.G429R	DO43466	UCEC	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.6457
p.G429S	DO48395	BLCA	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.5882
p.E440K	DO234270	ESAD	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.0556
p.P427L	DO11854	GBM	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.7582
p.P427T	DO229022	LICA	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.7031
p.P431T	DO229035	LICA	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.3056
p.R434W	DO228496	MALY	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.2222
p.R437C	DO48904	PBCA	ICGC	VTPSGS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRS8	La-related protein 6	DEG_SCF_FBW7_1	425:430	VTPSGS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPSGS

Degron related mutations and impact score

Drug responses associated with LARP6 mutations

All proteins holding degron of VTPSGS