DegronMD

Uniprot ID: Q9BRS8

Source protein: La-related protein 6

Source gene: LARP6

Class: DEG_APCC_KENBOX_2

Location: 282:286

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9927

ASA_SCORE: 80.2

COIL: 0.7152

CONS_SCORE: 0.5626

DSS_SCORE: 0.4294

HELIX: 0.1746

FCONS_SCORE: 1.1218

RIG_SCORE: 0.7182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I291T	TCGA-DX-AB2Q	SARC	TCGA	GKENM	DEG_APCC_KENBOX_2	0.1944
p.I291T	DO220087	SARC	ICGC	GKENM	DEG_APCC_KENBOX_2	0.1944
p.T278K	DO229037	LICA	ICGC	GKENM	DEG_APCC_KENBOX_2	0.2222
p.K283E	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	GKENM	DEG_APCC_KENBOX_2	0.7022
p.K283E	ACH-000837	Lung Cancer	CCLE	GKENM	DEG_APCC_KENBOX_2	0.7022
p.K283E	NCI-H322M	lung	COSMIC	GKENM	DEG_APCC_KENBOX_2	0.7022
p.H273Y	ACH-002202	Gastric Cancer	CCLE	GKENM	DEG_APCC_KENBOX_2	0.0833
p.H273Y	TMK-1	stomach	COSMIC	GKENM	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRS8	La-related protein 6	DEG_APCC_KENBOX_2	282:286	GKENM	APC,CDC20,FZR1	0.9927	More...
Q9NXL2	Rho guanine nucleotide exchange factor 38	DEG_APCC_KENBOX_2	8:12	GKENM	APC,CDC20,FZR1	0.9385	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons