DegronMD

Uniprot ID: Q9NXL2

Source protein: Rho guanine nucleotide exchange factor 38

Source gene: ARHGEF38

Class: DEG_APCC_KENBOX_2

Location: 8:12

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9385

ASA_SCORE: 107.06

COIL: 0.6476

CONS_SCORE: 0.7527

DSS_SCORE: 0.5944

HELIX: 0.3322

FCONS_SCORE: 0.9864

RIG_SCORE: 0.7111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A20V	TCGA-05-4397	LUAD	TCGA	GKENM	DEG_APCC_KENBOX_2	0.1111
p.A20V	DO25320	LUAD	ICGC	GKENM	DEG_APCC_KENBOX_2	0.1111
p.K17N	TCGA-AA-3510	COAD	TCGA	GKENM	DEG_APCC_KENBOX_2	0.3056
p.K17N	DO7783	COAD	ICGC	GKENM	DEG_APCC_KENBOX_2	0.3056
p.M12I	TCGA-CN-6010	HNSC	TCGA	GKENM	DEG_APCC_KENBOX_2	0.6507
p.M12I	DO14766	HNSC	ICGC	GKENM	DEG_APCC_KENBOX_2	0.6507
p.E2K	SIDM00955	Melanoma	GDSC	GKENM	DEG_APCC_KENBOX_2	0.1667
p.E2K	ACH-000812	Skin Cancer	CCLE	GKENM	DEG_APCC_KENBOX_2	0.1667
p.E2K	COLO-783	skin	COSMIC	GKENM	DEG_APCC_KENBOX_2	0.1667
p.F21L	SIDM01090	Colorectal Carcinoma	GDSC	GKENM	DEG_APCC_KENBOX_2	0.0833
p.F21L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	GKENM	DEG_APCC_KENBOX_2	0.0833
p.F21L	SIDM00650	Small Cell Lung Carcinoma	GDSC	GKENM	DEG_APCC_KENBOX_2	0.0833
p.F21L	SIDM01681	Non-Cancerous	GDSC	GKENM	DEG_APCC_KENBOX_2	0.0833
p.F21L	SIDM00808	Burkitt's Lymphoma	GDSC	GKENM	DEG_APCC_KENBOX_2	0.0833
p.F21L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	GKENM	DEG_APCC_KENBOX_2	0.0833
p.F21L	SIDM01254	Burkitt's Lymphoma	GDSC	GKENM	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRS8	La-related protein 6	DEG_APCC_KENBOX_2	282:286	GKENM	APC,CDC20,FZR1	0.9927	More...
Q9NXL2	Rho guanine nucleotide exchange factor 38	DEG_APCC_KENBOX_2	8:12	GKENM	APC,CDC20,FZR1	0.9385	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons