DegronMD - Q9NXL2(ARHGEF38)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A20V	TCGA-05-4397	LUAD	TCGA	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.1111
p.A20V	DO25320	LUAD	ICGC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.1111
p.K17N	TCGA-AA-3510	COAD	TCGA	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation substituting flanking lysine	0.3056
p.K17N	DO7783	COAD	ICGC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation substituting flanking lysine	0.3056
p.K67N	TCGA-AX-A2HC	UCEC	TCGA	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation rewiring degron network	0.3056
p.K67N	DO41572	UCEC	ICGC	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation rewiring degron network	0.3056
p.P82T	TCGA-CD-A4MJ	STAD	TCGA	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation rewiring degron network	0.0833
p.P82T	DO47811	STAD	ICGC	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation rewiring degron network	0.0833
p.P82T	SIDM00433	T-Lymphoblastic Leukemia	GDSC	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation rewiring degron network	0.0833
p.P82T	SIDM01759	Hodgkin's Lymphoma	GDSC	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation rewiring degron network	0.0833
p.M12I	TCGA-CN-6010	HNSC	TCGA	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation altering degron motif	0.6507
p.M12I	DO14766	HNSC	ICGC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation altering degron motif	0.6507
p.P82S	TCGA-D3-A2JK	SKCM	TCGA	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation rewiring degron network	0.0833
p.P82S	DO37619	SKCM	ICGC	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation rewiring degron network	0.0833
p.E2K	SIDM00955	Melanoma	GDSC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.1667
p.E2K	ACH-000812	Skin Cancer	CCLE	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.1667
p.E2K	COLO-783	skin	COSMIC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.1667
p.F21L	SIDM01090	Colorectal Carcinoma	GDSC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.0833
p.F21L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.0833
p.F21L	SIDM00650	Small Cell Lung Carcinoma	GDSC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.0833
p.F21L	SIDM01681	Non-Cancerous	GDSC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.0833
p.F21L	SIDM00808	Burkitt's Lymphoma	GDSC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.0833
p.F21L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.0833
p.F21L	SIDM01254	Burkitt's Lymphoma	GDSC	GKENM	DEG_APCC_KENBOX_2	8:12	Mutation rewiring degron network	0.0833
p.E73V	SIDM00735	Small Cell Lung Carcinoma	GDSC	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation altering degron motif	0.7693
p.E73V	ACH-000298	Lung Cancer	CCLE	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation altering degron motif	0.7693
p.E73V	NCI-H2029	lung	COSMIC	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation altering degron motif	0.7693
p.E59K	SIDM00003	Melanoma	GDSC	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation rewiring degron network	0.0833
p.E59K	M14	skin	COSMIC	MTPQGE	DEG_SCF_FBW7_2	68:73	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF38

UniProt ID: Q9NXL2

Entrez ID: 54848

Protein name: Rho guanine nucleotide exchange factor 38

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARHGEF38 in