DegronMD

Uniprot ID: Q9NXL2

Source protein: Rho guanine nucleotide exchange factor 38

Source gene: ARHGEF38

Class: DEG_SCF_FBW7_2

Location: 68:73

E3 ligase: FBXW7

DEGRON score: 0.5707

ASA_SCORE: 94.85

COIL: 0.8852

CONS_SCORE: 0.7527

DSS_SCORE: 0.6008

HELIX: 0.075

FCONS_SCORE: 1.0414

RIG_SCORE: 0.6498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K67N	TCGA-AX-A2HC	UCEC	TCGA	MTPQGE	DEG_SCF_FBW7_2	0.3056
p.K67N	DO41572	UCEC	ICGC	MTPQGE	DEG_SCF_FBW7_2	0.3056
p.P82T	TCGA-CD-A4MJ	STAD	TCGA	MTPQGE	DEG_SCF_FBW7_2	0.0833
p.P82T	DO47811	STAD	ICGC	MTPQGE	DEG_SCF_FBW7_2	0.0833
p.P82T	SIDM00433	T-Lymphoblastic Leukemia	GDSC	MTPQGE	DEG_SCF_FBW7_2	0.0833
p.P82T	SIDM01759	Hodgkin's Lymphoma	GDSC	MTPQGE	DEG_SCF_FBW7_2	0.0833
p.P82S	TCGA-D3-A2JK	SKCM	TCGA	MTPQGE	DEG_SCF_FBW7_2	0.0833
p.P82S	DO37619	SKCM	ICGC	MTPQGE	DEG_SCF_FBW7_2	0.0833
p.E73V	SIDM00735	Small Cell Lung Carcinoma	GDSC	MTPQGE	DEG_SCF_FBW7_2	0.7693
p.E73V	ACH-000298	Lung Cancer	CCLE	MTPQGE	DEG_SCF_FBW7_2	0.7693
p.E73V	NCI-H2029	lung	COSMIC	MTPQGE	DEG_SCF_FBW7_2	0.7693
p.E59K	SIDM00003	Melanoma	GDSC	MTPQGE	DEG_SCF_FBW7_2	0.0833
p.E59K	M14	skin	COSMIC	MTPQGE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXL2	Rho guanine nucleotide exchange factor 38	DEG_SCF_FBW7_2	68:73	MTPQGE	FBXW7	0.5707	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons