DegronMD

Uniprot ID: P80192

Source protein: Mitogen-activated protein kinase kinase kinase 9

Source gene: MAP3K9

Class: DEG_SPOP_SBC_1

Location: 1021:1025

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 78.24

COIL: 0.9334

CONS_SCORE: 0.4806

DSS_SCORE: 0.6348

HELIX: 0.0494

FCONS_SCORE: 1.0976

RIG_SCORE: 0.5232

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1017Q	TCGA-BG-A222	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.2222
p.R1017W	TCGA-CM-6162	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.2222
p.R1015Q	TCGA-CV-A45O	HNSC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1667
p.N1014Y	TCGA-EE-A29H	SKCM	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1389
p.P1034Q	TCGA-F5-6864	READ	TCGA	ANSSS	DEG_SPOP_SBC_1	0.0833
p.R1030C	TCGA-G4-6309	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1944
p.A1013V	TCGA-VQ-A924	STAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1111
p.A1028D	DO229041	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	0.25
p.P1024R	DO23645	LUAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.7512
p.S1011T	DO25040	LUAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.0556
p.S1018N	DO51407	PRAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.25
p.E1021D	DO47278	SKCM	ICGC	ANSSS	DEG_SPOP_SBC_1	0.6758
p.V1020I	DO51785	STAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.3056
p.T1032A	SIDM00845	Burkitt's Lymphoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.1389
p.N1014H	SIDM00491	Thyroid Gland Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.1389
p.N1014H	ASH-3	thyroid	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.1389
p.R1015W	SIDM00789	Colorectal Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.1667
p.T1026I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.3056
p.T1019I	NCI-H1155	lung	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.2778
p.V1024L	HCC70	breast	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	213:217	ANSSS	SPOP	0.9966	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1879:1883	ANSSS	SPOP	0.986	More...
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SPOP_SBC_1	1021:1025	ANSSS	SPOP	0.9968	More...
Q06945	Transcription factor SOX-4	DEG_SPOP_SBC_1	139:143	ANSSS	SPOP	0.9719	More...
Q6UWB1	Interleukin-27 receptor subunit alpha	DEG_SPOP_SBC_1	562:566	ANSSS	SPOP	0.7903	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	551:555	ANSSS	SPOP	0.983	More...
Q8IZW8	Tensin-4	DEG_SPOP_SBC_1	311:315	ANSSS	SPOP	0.8185	More...
Q99743	Neuronal PAS domain-containing protein 2	DEG_SPOP_SBC_1	720:724	ANSSS	SPOP	0.9105	More...
Q9BRS8	La-related protein 6	DEG_SPOP_SBC_1	336:340	ANSSS	SPOP	0.9686	More...
Q9HCD5	Nuclear receptor coactivator 5	DEG_SPOP_SBC_1	446:450	ANSSS	SPOP	0.8794	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_SPOP_SBC_1	729:733	ANSSS	SPOP	0.8431	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	73:77	ANSSS	SPOP	0.9841	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_SPOP_SBC_1	775:779	ANSSS	SPOP	0.9091	More...
Q9H1C0	Lysophosphatidic acid receptor 5	DEG_SPOP_SBC_1	3:7	ANSSS	SPOP	0.6526	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	429:433	ANSSS	SPOP	0.756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons