DegronMD - Q06945(SOX4)

GO - Biological processes (BP): anatomical structure morphogenesis [GO:0009653]; ascending aorta morphogenesis [GO:0035910]; atrial septum primum morphogenesis [GO:0003289]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; cellular response to glucose stimulus [GO:0071333]; endocrine pancreas development [GO:0031018]; glial cell development [GO:0021782]; glial cell proliferation [GO:0014009]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; hematopoietic stem cell homeostasis [GO:0061484]; kidney morphogenesis [GO:0060993]; limb bud formation [GO:0060174]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell death [GO:0060548]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein ubiquitination [GO:0031397]; neural tube formation [GO:0001841]; neuroepithelial cell differentiation [GO:0060563]; noradrenergic neuron differentiation [GO:0003357]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of insulin secretion [GO:0032024]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of N-terminal peptidyl-lysine acetylation [GO:2000761]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein stabilization [GO:0050821]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of protein stability [GO:0031647]; regulation of transcription, DNA-templated [GO:0006355]; skeletal system development [GO:0001501]; somatic stem cell population maintenance [GO:0035019]; spinal cord development [GO:0021510]; spinal cord motor neuron differentiation [GO:0021522]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; ventricular septum morphogenesis [GO:0060412] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S41P	TCGA-63-A5MI	LUSC	TCGA	PTPGST	DEG_SCF_FBW7_1	34:39	Mutation rewiring degron network	0.2778
p.S41P	DO219147	LUSC	ICGC	PTPGST	DEG_SCF_FBW7_1	34:39	Mutation rewiring degron network	0.2778
p.R131M	TCGA-DU-6392	LGG	TCGA	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.R131M	DO22237	LGG	ICGC	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.V134M	TCGA-EC-A24G	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.V134M	DO40996	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.R131S	TCGA-EE-A2MN	SKCM	TCGA	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.R131S	DO37423	SKCM	ICGC	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.G25C	TCGA-HT-A4DS	LGG	TCGA	PTPGST	DEG_SCF_FBW7_1	34:39	Mutation rewiring degron network	0.0833
p.G25C	DO44554	LGG	ICGC	PTPGST	DEG_SCF_FBW7_1	34:39	Mutation rewiring degron network	0.0833
p.A145T	DO233882	GACA	ICGC	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.A24G	DO33028	PACA	ICGC	PTPGST	DEG_SCF_FBW7_1	34:39	Mutation rewiring degron network	0.0556
p.D317N	DO229224	THCA	ICGC	LGLYEE	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.1944
p.D320Y	DO229224	THCA	ICGC	LGLYEE	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.2778
p.E327K	SIDM00845	Burkitt's Lymphoma	GDSC	LGLYEE	LIG_APCC_ABBA_1	322:327	Mutation altering degron motif	0.7022
p.P318L	SIDM00210	Ovarian Carcinoma	GDSC	LGLYEE	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.2222
p.P318L	ACH-000657	Ovarian Cancer	CCLE	LGLYEE	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.2222
p.A139T	SIDM00438	B-Lymphoblastic Leukemia	GDSC	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7139
p.A139T	ACH-002275	Leukemia	CCLE	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7139
p.A139T	MN-60	haematopoietic and lymphoid tissue	COSMIC	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7139
p.E326K	SIDM00316	Glioblastoma	GDSC	LGLYEE	LIG_APCC_ABBA_1	322:327	Mutation altering degron motif	0.591
p.E326K	ACH-001197	Lymphoma	CCLE	LGLYEE	LIG_APCC_ABBA_1	322:327	Mutation altering degron motif	0.591
p.S144L	SIDM01776	Plasma Cell Myeloma	GDSC	ANSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.3056
p.C332Y	ACH-000971	Colon/Colorectal Cancer	CCLE	LGLYEE	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.1944

Kaplan plot for SOX4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOX4

UniProt ID: Q06945

Entrez ID: 6659

Protein name: Transcription factor SOX-4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOX4 in