DegronMD

Uniprot ID: Q06945

Source protein: Transcription factor SOX-4

Source gene: SOX4

Class: LIG_APCC_ABBA_1

Location: 322:327

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9351

ASA_SCORE: 67.55

COIL: 0.592

CONS_SCORE: 0.6108

DSS_SCORE: 0.6108

HELIX: 0.238

FCONS_SCORE: 1.141

RIG_SCORE: 0.7292

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D317N	DO229224	THCA	ICGC	LGLYEE	LIG_APCC_ABBA_1	0.1944
p.D320Y	DO229224	THCA	ICGC	LGLYEE	LIG_APCC_ABBA_1	0.2778
p.E327K	SIDM00845	Burkitt's Lymphoma	GDSC	LGLYEE	LIG_APCC_ABBA_1	0.7022
p.P318L	SIDM00210	Ovarian Carcinoma	GDSC	LGLYEE	LIG_APCC_ABBA_1	0.2222
p.P318L	ACH-000657	Ovarian Cancer	CCLE	LGLYEE	LIG_APCC_ABBA_1	0.2222
p.E326K	SIDM00316	Glioblastoma	GDSC	LGLYEE	LIG_APCC_ABBA_1	0.591
p.E326K	ACH-001197	Lymphoma	CCLE	LGLYEE	LIG_APCC_ABBA_1	0.591
p.C332Y	ACH-000971	Colon/Colorectal Cancer	CCLE	LGLYEE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06945	Transcription factor SOX-4	LIG_APCC_ABBA_1	322:327	LGLYEE	APC,CDC20,FZR1	0.9351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons