DegronMD

Uniprot ID: Q06945

Source protein: Transcription factor SOX-4

Source gene: SOX4

Class: DEG_SCF_FBW7_1

Location: 34:39

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 74.5

COIL: 0.9367

CONS_SCORE: 0.5695

DSS_SCORE: 0.6322

HELIX: 0.0227

FCONS_SCORE: 1.134

RIG_SCORE: 0.555

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S41P	TCGA-63-A5MI	LUSC	TCGA	PTPGST	DEG_SCF_FBW7_1	0.2778
p.S41P	DO219147	LUSC	ICGC	PTPGST	DEG_SCF_FBW7_1	0.2778
p.G25C	TCGA-HT-A4DS	LGG	TCGA	PTPGST	DEG_SCF_FBW7_1	0.0833
p.G25C	DO44554	LGG	ICGC	PTPGST	DEG_SCF_FBW7_1	0.0833
p.A24G	DO33028	PACA	ICGC	PTPGST	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06945	Transcription factor SOX-4	DEG_SCF_FBW7_1	34:39	PTPGST	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons