DegronMD - P80192(MAP3K9)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1061R	TCGA-44-6777	LUAD	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.1111
p.E1041D	TCGA-4Z-AA89	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.6758
p.S1048T	TCGA-50-5066	LUAD	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation altering degron motif	0.7116
p.P617T	TCGA-50-6673	LUAD	TCGA	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0833
p.P617T	DO24218	LUAD	ICGC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0833
p.S627I	TCGA-55-A4DG	LUAD	TCGA	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.623
p.S627I	DO26337	LUAD	ICGC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.623
p.R558C	TCGA-59-2349	OV	TCGA	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.2222
p.R558C	DO28621	OV	ICGC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.2222
p.W573C	TCGA-AB-2833	LAML	TCGA	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.2222
p.W573C	DO21679	LAML	ICGC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.2222
p.S954N	TCGA-B5-A3FA	UCEC	TCGA	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.2778
p.R1017Q	TCGA-BG-A222	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.2222
p.A942T	TCGA-BG-A222	UCEC	TCGA	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.25
p.L951F	TCGA-C8-A275	BRCA	TCGA	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.6981
p.T572P	TCGA-CG-4460	STAD	TCGA	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.25
p.T572P	DO38427	STAD	ICGC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.25
p.R558H	TCGA-CG-4460	STAD	TCGA	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.2222
p.R558H	DO38427	STAD	ICGC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.2222
p.R1017W	TCGA-CM-6162	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.2222
p.R1015Q	TCGA-CV-A45O	HNSC	TCGA	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1667
p.E1058D	TCGA-D3-A2JL	SKCM	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.1944
p.R560L	TCGA-D3-A2JP	SKCM	TCGA	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.2778
p.R560L	DO47407	SKCM	ICGC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.2778
p.F717L	TCGA-D3-A5GL	SKCM	TCGA	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.2222
p.S945N	TCGA-D3-A8GI	SKCM	TCGA	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.7069
p.N1014Y	TCGA-EE-A29H	SKCM	TCGA	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1389
p.S616F	TCGA-EE-A2MT	SKCM	TCGA	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation blocking phosphorylation signal	0.5
p.S616F	DO38051	SKCM	ICGC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation blocking phosphorylation signal	0.5
p.G956V	TCGA-ER-A1A1	SKCM	TCGA	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.2222
p.L713I	TCGA-EY-A215	UCEC	TCGA	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.1111
p.P1034Q	TCGA-F5-6864	READ	TCGA	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.0833
p.P1034Q	TCGA-F5-6864	READ	TCGA	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.25
p.E621V	TCGA-F7-A623	HNSC	TCGA	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1944
p.E621V	DO44443	HNSC	ICGC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1944
p.G720R	TCGA-FR-A3R1	SKCM	TCGA	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.3056
p.R1030C	TCGA-G4-6309	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1944
p.R1030C	TCGA-G4-6309	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1389
p.D724N	TCGA-GD-A3OQ	BLCA	TCGA	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation altering degron motif	0.6932
p.P557S	TCGA-GN-A266	SKCM	TCGA	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.1944
p.P557S	DO37432	SKCM	ICGC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.1944
p.T1042M	TCGA-QQ-A8VF	SARC	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.25
p.T1042M	TCGA-QQ-A8VF	SARC	TCGA	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.3056
p.V1057I	TCGA-VQ-A91K	STAD	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.2222
p.A1013V	TCGA-VQ-A924	STAD	TCGA	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1111
p.R719C	TCGA-W3-A824	SKCM	TCGA	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.2778
p.D722Y	TCGA-WE-AA9Y	SKCM	TCGA	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation altering degron motif	0.7325
p.S1055N	TCGA-XK-AAIW	PRAD	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.2778
p.H723P	DO48393	BLCA	ICGC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation altering degron motif	0.7694
p.G732S	DO219005	BLCA	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation altering degron motif	0.6993
p.P936A	DO3852	BRCA	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0833
p.L637S	DO227987	COCA	ICGC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1944
p.G741C	DO222503	COCA	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.25
p.V736A	DO233942	GACA	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation altering degron motif	0.6936
p.R937H	DO219054	HNSC	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.1111
p.R725H	DO22237	LGG	ICGC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation altering degron motif	0.8244
p.P557T	DO228986	LICA	ICGC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.1944
p.N953K	DO229025	LICA	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.3056
p.A1028D	DO229041	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.25
p.A1028D	DO229041	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.0833
p.P1039Q	DO229008	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7035
p.R718W	DO49657	LIHC	ICGC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.25
p.G743W	DO23838	LUAD	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.1944
p.P1024R	DO23645	LUAD	ICGC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7512
p.S1011T	DO25040	LUAD	ICGC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.0556
p.V736I	DO231141	LUSC	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation altering degron motif	0.7076
p.K622N	DO222402	MELA	ICGC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation substituting flanking lysine	0.3333
p.A721V	DO222702	MELA	ICGC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation altering degron motif	0.6936
p.R950W	DO222911	MELA	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.8634
p.D957G	DO232761	PBCA	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.1944
p.S1018N	DO51407	PRAD	ICGC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.25
p.K717R	DO220176	SARC	ICGC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.2222
p.L938F	DO229446	SKCA	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation blocking phosphorylation signal	0.5833
p.E727D	DO37571	SKCM	ICGC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.3056
p.E727D	DO37571	SKCM	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.2222
p.P1039S	DO37567	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.6752
p.E1021D	DO47278	SKCM	ICGC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.6758
p.E1050K	DO50284	SKCM	ICGC	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation altering degron motif	0.7022
p.G1051E	DO51282	SKCM	ICGC	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation altering degron motif	0.7199
p.P1038A	DO219503	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7503
p.V1020I	DO51785	STAD	ICGC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.3056
p.Q618R	DO229234	THCA	ICGC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1111
p.P1059S	DO40879	UCEC	ICGC	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.1667
p.P1059L	DO43306	UCEC	ICGC	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.1667
p.R951H	DO43682	UCEC	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.8244
p.E727K	DO52399	UCEC	ICGC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.3056
p.E727K	DO52399	UCEC	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.2222
p.L730M	DO41644	UCEC	ICGC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.2222
p.L730M	DO41644	UCEC	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.3056
p.C1061Y	DO41235	UCEC	ICGC	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.1111
p.K624N	DO41235	UCEC	ICGC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.2778
p.F935L	DO41488	UCEC	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.T1040I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7078
p.T1040I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7078
p.T1040I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7078
p.T1032A	SIDM00845	Burkitt's Lymphoma	GDSC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1389
p.T1032A	SIDM00845	Burkitt's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1944
p.R719H	SIDM00473	Oral Cavity Carcinoma	GDSC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.2778
p.N1014H	SIDM00491	Thyroid Gland Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1389
p.N1014H	ASH-3	thyroid	COSMIC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1389
p.R1015W	SIDM00789	Colorectal Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1667
p.G730R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.2222
p.G730R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.3056
p.G730R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.2222
p.G730R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.3056
p.P745S	SIDM01106	Melanoma	GDSC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.1389
p.P745S	SK-MEL-24	skin	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.1389
p.V579I	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.0556
p.V579I	SIDM01155	Glioma	GDSC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.0556
p.V579I	SW1088	central nervous system	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.0556
p.V579I	NCI-H1869	lung	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.0556
p.T1056I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.25
p.T1056I	NCI-H1155	lung	COSMIC	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.25
p.E631K	SIDM00414	Bladder Carcinoma	GDSC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.591
p.E631K	ACH-000545	Bladder Cancer	CCLE	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.591
p.E631K	VM-CUB-1	urinary tract	COSMIC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.591
p.H634D	SIDM00242	Osteosarcoma	GDSC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.2778
p.H634D	ACH-002067	Bone Cancer	CCLE	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.2778
p.H634D	NOS-1	bone	COSMIC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.2778
p.V579F	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.0556
p.V579F	Calu-6	lung	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.0556
p.N577Y	ACH-000754	Lymphoma	CCLE	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.1111
p.N577Y	L-428	haematopoietic and lymphoid tissue	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.1111
p.R718S	ACH-000830	Lung Cancer	CCLE	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.25
p.R718S	NCI-H1436	lung	COSMIC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.25
p.D560E	ACH-000921	Lung Cancer	CCLE	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.2778
p.P1062L	ACH-000937	Leukemia	CCLE	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.0833
p.P1062L	PF-382	haematopoietic and lymphoid tissue	COSMIC	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.0833
p.E619Q	ACH-000975	Lung Cancer	CCLE	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1389
p.E619Q	H513	pleura	COSMIC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1389
p.R734W	ACH-000997	Colon/Colorectal Cancer	CCLE	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation altering degron motif	0.8634
p.R734W	ACH-001061	Colon/Colorectal Cancer	CCLE	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation altering degron motif	0.8634
p.N733H	ACH-001443	Thyroid Cancer	CCLE	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation altering degron motif	0.7423
p.N733H	ASH-3	thyroid	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation altering degron motif	0.7423
p.T635I	ACH-001515	Cervical Cancer	CCLE	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.25
p.P727L	NCI-H1355	lung	COSMIC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.3056
p.P727L	NCI-H1355	lung	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.2222
p.R747H	TMK-1	stomach	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.0833
p.R747H	PC-3_[JPC-3]	lung	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.0833
p.R713S	NCI-H1436	lung	COSMIC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.1111
p.G716R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.1944
p.P738L	GP5d	large intestine	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation altering degron motif	0.7582
p.N620Y	L-428	haematopoietic and lymphoid tissue	COSMIC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1667
p.P947A	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.7503
p.R729Q	TE-9	oesophagus	COSMIC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.25
p.R729Q	TE-9	oesophagus	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.2778
p.N572Y	L-428	haematopoietic and lymphoid tissue	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.25
p.V738L	HCC70	breast	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation altering degron motif	0.6765
p.R570W	SW1783	central nervous system	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.3056
p.R570W	NCI-H1155	lung	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.3056
p.R570W	HEC-1	endometrium	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.3056
p.E938G	HGC-27	stomach	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation blocking phosphorylation signal	0.5833
p.R564W	KYSE-450	oesophagus	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation altering degron motif	0.8634
p.P1039L	PF-382	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7582
p.R724H	TMK-1	stomach	COSMIC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation altering degron motif	0.8244
p.R724H	PC-3_[JPC-3]	lung	COSMIC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation altering degron motif	0.8244
p.R741Q	Hs633T	soft tissue	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.25
p.V743L	HCC70	breast	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.1944
p.P962L	GP5d	large intestine	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.R953Q	TE-9	oesophagus	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.3056
p.R962S	NCI-H1436	lung	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.0556
p.D745H	NCI-H526	lung	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.1389
p.R718Q	Hs633T	soft tissue	COSMIC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.25
p.P731S	SK-MEL-24	skin	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation altering degron motif	0.6752
p.A563V	OVCA420	ovary	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation altering degron motif	0.6936
p.P746A	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.1111
p.S1056N	MDA-MB-231	breast	COSMIC	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.25
p.T1026I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.3056
p.P939L	GP5d	large intestine	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation rewiring degron network	0.1667
p.N728H	ASH-3	thyroid	COSMIC	PTPVNS	DEG_SCF_FBW7_1	721:726	Mutation rewiring degron network	0.2778
p.N728H	ASH-3	thyroid	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	731:738	Mutation rewiring degron network	0.25
p.R569T	FADU	upper aerodigestive tract	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	562:569	Mutation altering degron motif	0.7876
p.R642Q	SW1783	central nervous system	COSMIC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0556
p.T1019I	NCI-H1155	lung	COSMIC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.2778
p.V1024L	HCC70	breast	COSMIC	ANSSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.6765
p.P951L	NCI-H1355	lung	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	945:952	Mutation altering degron motif	0.6471
p.R642W	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LSTPSES	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0556
p.T1042I	NCI-H1155	lung	COSMIC	ERPGLPALL	DEG_APCC_DBOX_1	1045:1053	Mutation rewiring degron network	0.25
p.T1042I	NCI-H1155	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K9

UniProt ID: P80192

Entrez ID: 4293

Protein name: Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K9 in