DegronMD

Uniprot ID: P80192

Source protein: Mitogen-activated protein kinase kinase kinase 9

Source gene: MAP3K9

Class: DEG_SCF_FBW7_1

Location: 731:738

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 84.4875

COIL: 0.9205

CONS_SCORE: 0.4371

DSS_SCORE: 0.669

HELIX: 0.0584

FCONS_SCORE: 1.0666

RIG_SCORE: 0.6861

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G732S	DO219005	BLCA	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	0.6993
p.G741C	DO222503	COCA	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	0.25
p.V736A	DO233942	GACA	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	0.6936
p.G743W	DO23838	LUAD	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	0.1944
p.V736I	DO231141	LUSC	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	0.7076
p.E727D	DO37571	SKCM	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	0.2222
p.E727K	DO52399	UCEC	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	0.2222
p.L730M	DO41644	UCEC	ICGC	PQLTPTNS	DEG_SCF_FBW7_1	0.3056
p.G730R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PQLTPTNS	DEG_SCF_FBW7_1	0.3056
p.G730R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.3056
p.P745S	SIDM01106	Melanoma	GDSC	PQLTPTNS	DEG_SCF_FBW7_1	0.1389
p.P745S	SK-MEL-24	skin	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.1389
p.R734W	ACH-000997	Colon/Colorectal Cancer	CCLE	PQLTPTNS	DEG_SCF_FBW7_1	0.8634
p.R734W	ACH-001061	Colon/Colorectal Cancer	CCLE	PQLTPTNS	DEG_SCF_FBW7_1	0.8634
p.N733H	ACH-001443	Thyroid Cancer	CCLE	PQLTPTNS	DEG_SCF_FBW7_1	0.7423
p.N733H	ASH-3	thyroid	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.7423
p.P727L	NCI-H1355	lung	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.2222
p.R747H	TMK-1	stomach	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.0833
p.R747H	PC-3_[JPC-3]	lung	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.0833
p.P738L	GP5d	large_intestine	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.7582
p.R729Q	TE-9	oesophagus	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.2778
p.V738L	HCC70	breast	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.6765
p.R741Q	Hs633T	soft_tissue	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.25
p.V743L	HCC70	breast	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.1944
p.D745H	NCI-H526	lung	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.1389
p.P731S	SK-MEL-24	skin	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.6752
p.P746A	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.1111
p.N728H	ASH-3	thyroid	COSMIC	PQLTPTNS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQLTPTNS

Degron related mutations and impact score

Drug responses associated with MAP3K9 mutations

All proteins holding degron of PQLTPTNS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SCF_FBW7_1	731:738	PQLTPTNS	FBXW7	0.9956	More...